Statin Use Is Associated With Improved Prognosis of Colorectal Cancer in Taiwan

Clinical Colorectal Cancer
Yu-Yun ShaoMei-Shu Lai

Abstract

Statins are widely used for hyperlipidemia control and might also exhibit anticancer properties. This study explored whether statin use is associated with the prognosis of curatively resected colorectal cancer (CRC). Using data from the Taiwan Cancer Registry, we established a population-based cohort of patients who received curative surgery for stage I, II, or III CRC. Data related to prescription medications and comorbidities were retrieved from the database of the National Health Insurance program of Taiwan. Statin users were defined as patients who had used statins within 1 year before their cancer diagnosis. Univariate and multivariate analyses were used to compare cancer-specific survival (CSS) and overall survival (OS) between statin users and patients who had never used statins (never users). In the multivariate analysis, we used propensity scores to adjust for age, sex, diagnosis year, physician visits, hospitalization, conjunctive medications, and comorbidities. A total of 17,115 patients were enrolled; 2145 (13%) of these patients were statin users, and 14,970 (87%) were never users. After adjusting for other potential prognostic factors, statin use was an independent predictor for longer CSS (hazard ratio [HR], 0.77...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Feb 1, 1990·Nature·J L Goldstein, M S Brown
Apr 14, 1995·Science·P J Casey
Dec 5, 1998·The New England Journal of Medicine·UNKNOWN Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
Jan 13, 2000·The New England Journal of Medicine·R GryfeS Gallinger
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Jun 22, 2002·JAMA : the Journal of the American Medical Association·Patrick W J C SerruysUNKNOWN Lescol Intervention Prevention Study (LIPS) Investigators
Dec 13, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sanjay PopatMary O'Brien
Dec 16, 2006·Current Atherosclerosis Reports·Sridevi DevarajIshwarlal Jialal
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alberto MalesciArmando Santoro
Apr 2, 2009·Digestive Diseases and Sciences·Ali A SiddiquiStuart J Spechler
Nov 10, 2009·International Journal of Colorectal Disease·Heike Knüpfer, Rainer Preiss
Dec 17, 2009·Expert Opinion on Drug Safety·M Wasif Saif
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
Apr 28, 2010·Current Opinion in Cardiology·Petter Quist-Paulsen
May 25, 2010·Japanese Journal of Clinical Oncology·Chun-Ju ChiangUNKNOWN Taiwan Cancer Registry Task Force
Sep 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maria CoimbraRaymond M Schiffelers
Jan 21, 2011·Current Cancer Drug Targets·Lidija Klampfer
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gordon HutchinsPhilip Quirke
Aug 19, 2011·Journal of the National Cancer Institute·Kimmie NgCharles S Fuchs
Oct 5, 2012·Current Medicinal Chemistry·N VazzanaP Ferroni
Nov 9, 2012·The New England Journal of Medicine·Sune F NielsenStig E Bojesen
Nov 20, 2012·International Journal of Cancer. Journal International Du Cancer·Adetunji T ToriolaCornelia M Ulrich
Oct 10, 2013·Diseases of the Colon and Rectum·Adam G MaceMatthew F Kalady

❮ Previous
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Citations

Oct 22, 2016·Journal of Internal Medicine·A Kautzky-WillerP Klimek
Feb 16, 2018·Journal of Lipid Research·Heike GottschallKarsten H Weylandt
Nov 13, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Yusuke KobayashiDaisuke Aoki
Dec 18, 2019·ANZ Journal of Surgery·Dimitrios KaraviasUNKNOWN Nottingham HPB Surgery Group
Jul 12, 2017·Journal of Clinical Gastroenterology·Baoge Qu, Hao Qu
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Zubing MeiWei Yang
Aug 12, 2020·Journal of Hematology & Oncology·Rong TangSi Shi
Sep 27, 2018·Frontiers in Endocrinology·Ivan CasaburiVincenzo Pezzi
Feb 6, 2019·Frontiers in Endocrinology·Adele ChimentoRosa Sirianni
Mar 25, 2017·American Journal of Epidemiology·Timothy L LashOle Thorlacius-Ussing
Mar 5, 2021·Clinics and Research in Hepatology and Gastroenterology·Liusheng LiWu Yu

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