Statin use is associated with improved survival in multiple myeloma: A Swedish population-based study of 4315 patients

American Journal of Hematology
Elsa BrånvallKarin E Smedby

Abstract

Statin use has been associated with reduced cancer-specific mortality among patients with several cancer types, including multiple myeloma (MM). We aimed to further elucidate the association of statin use and dose intensity with MM survival. Using Swedish population-based national health registers, we identified all incident MM diagnoses occurring January 1, 2007 to December 31, 2013 and their drug dispensations and comorbidities. We assessed statin exposure in 6-month periods pre- and post-diagnosis, treated diagnosis as baseline for calculating survival time, and calculated hazard ratios (HR) and 95% confidence intervals (CI) of exposure-related MM-specific and all-cause mortality using Cox regression. We assessed statin exposure during the entire follow-up and risk of MM-specific mortality in a nested case-control analysis. We classified dose intensity according to American College of Cardiology/American Heart Association recommendations. We ascertained 4315 MM cases during follow-up. Statin use was associated with reduced MM-specific mortality (pre-diagnosis use multivariate-adjusted HR, 95% CI: 0.83, 0.71-0.96; 6 months post-diagnosis: 0.73, 0.60-0.89; entire follow-up: 0.65, 0.52-0.80) and (more weakly) with all-cause mor...Continue Reading

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Citations

Jul 7, 2020·Frontiers in Chemistry·Elisabetta Di BelloSergio Valente
Feb 19, 2021·The Journal of Experimental Medicine·Xueli BianZhimin Lu
Apr 7, 2021·Heart·Marta Fontes OliveiraCharlotte Manisty
Jun 11, 2021·Frontiers in Oncology·Isabella GiacominiVeronica Cocetta
Jun 16, 2021·Biochemical Pharmacology·Kush K Patel, Khosrow Kashfi

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