Statin use is associated with lower risk of atrial fibrillation in women with coronary disease: the HERS trial

Heart
C N PellegriniGregory M Marcus

Abstract

To determine the efficacy of statin treatment in atrial fibrillation (AF) prevention in women. Cohort study using data obtained in the Heart and Estrogen/Progestin Replacement Study (HERS). Secondary analysis of a multicentre, randomised controlled clinical trial. 2673 Postmenopausal women with coronary disease. AF prevalence at baseline and incident AF over a mean follow-up of 4.1 years. 88 Women with AF were identified: 29 at baseline and 59 during follow-up. Women with AF were significantly less likely to be taking a statin at study enrollment than those without AF (22% vs 37%, p = 0.003). Baseline statin use was associated with a 65% lower odds of having AF at baseline after controlling for age, race, history of myocardial infarction or revascularisation and history of heart failure (odds ratio 0.35, 95% confidence interval (CI) 0.13 to 0.93, p = 0.04). The risk of developing AF during the study among those free from AF at baseline, adjusted for the same covariates, was 55% less for those receiving statin treatment (hazard ratio 0.45, 95% CI 0.26 to 0.78, p = 0.004). Statin treatment is associated with a lower prevalence and incidence of AF after adjustment for potential confounders in postmenopausal women with coronary dis...Continue Reading

References

Jan 13, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Dimpi PatelA Natale
Feb 25, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Irene SavelievaA J Camm
Jan 19, 2013·International Journal of Medical Sciences·Xue ZhouYun-qing Chen
Jul 11, 2009·Expert Review of Cardiovascular Therapy·Marcelle D Smit, Isabelle C Van Gelder
Jan 26, 2011·Journal of Clinical Lipidology·Yi Lin LeeSteven R Jones
Jan 22, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael PazianasChristopher L-H Huang
Feb 19, 2011·Journal of the American College of Cardiology·Serge SicouriCharles Antzelevitch
Nov 21, 2009·Journal of the American College of Cardiology·L Julian HaywoodALLHAT Collaborative Research Group
Dec 24, 2013·International Journal of Cardiology·Sevket BaltaMurat Unlu
Aug 5, 2014·Korean Circulation Journal·Chen-Ying HungTsu-Juey Wu

Citations

Jan 1, 1992·Journal of Electrocardiology·Pentti RautaharjuB R Chaitman
May 1, 1990·The American Journal of Cardiology·H S CabinA R Feinstein
Sep 28, 1995·The American Journal of Cardiology·J Kjekshus, T R Pedersen
Jul 8, 1998·Journal of Cardiovascular Electrophysiology·J A Larsen, A H Kadish
Nov 24, 1998·Pacing and Clinical Electrophysiology : PACE·K HnatkovaM Malik
Jan 14, 1999·The New England Journal of Medicine·R Ross
Feb 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Sven WassmannGeorg Nickenig
Nov 1, 2002·The New England Journal of Medicine·Saif S RathoreHarlan M Krumholz
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Dec 17, 2003·The American Journal of Cardiology·Yinong Young-XuShmuel Ravid
Mar 17, 2004·The American Journal of Cardiology·Arnljot TveitLars Gullestad
Aug 18, 2004·Circulation·Donald Lloyd-JonesEmelia J Benjamin
Jun 7, 2005·Journal of the American College of Cardiology·Jeff S HealeyStuart J Connolly
Nov 18, 2005·American Heart Journal·John Dernellis, Maria Panaretou
Dec 27, 2005·The American Journal of Cardiology·Francisco MarínMariano Valdés
Jan 19, 2006·JAMA : the Journal of the American Medical Association·Jeffrey S BergerDavid L Brown
Mar 1, 2006·Critical Care Medicine·Massimo ChelloElvio Covino
May 9, 2006·The American Journal of Cardiology·Mehmet OzaydinAhmet Altinbas
Aug 1, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ibrahim R HannaJonathan J Langberg
Aug 5, 2006·Stroke; a Journal of Cerebral Circulation·Michael D HillPROACT-2 Investigators
Dec 30, 2006·Circulation·Wayne RosamondAmerican Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 6, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Gregory M MarcusJeffrey E Olgin
Jun 27, 2007·Journal of Cardiovascular Electrophysiology·M Obadah Al ChekakieDavid J Wilber
Oct 31, 2007·American Heart Journal·Karin H HumphriesCARAF Investigators
Nov 21, 2007·Journal of the American College of Cardiology·Tim T IssacNasser M Lakkis
Nov 24, 2007·American Heart Journal·A Selcuk AdabagHanna E Bloomfield
Dec 18, 2007·Heart·Felicita Andreotti, Nicola Marchese
Dec 21, 2007·Nature Clinical Practice. Cardiovascular Medicine·Irina Savelieva, John Camm
Jan 16, 2008·Heart·Christopher J Boos, Gregory Y H Lip

Related Concepts

Incidence Studies
Myocardial Infarction
Atrial Fibrillation
Postmenopause
Progestin [EPC]
Estrogen Progestin Replacement Therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Old Myocardial Infarction
Progestins
Coronary Heart Disease

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