Statins and Colorectal Cancer - A Systematic Review

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Małgorzata DobrzyckaJarek Kobiela

Abstract

Statins act by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase and are an important drug class in the treatment of lipid disorders. They lower cholesterol levels and modulate cardiovascular disease risk in both primary and secondary prevention. In addition, some studies have shown that statins may have an effect on colorectal cancer development and treatment. Our objective is to summarize published studies on the effect of statins on colorectal carcinogenesis. A systematic review of the PubMed and Cochrane databases was performed to identify studies published between April 2010 and April 2018 that investigated the association between statin use and colorectal cancer incidence, mortality, and treatment. Overall, 126 articles were identified with our search strategy. Based on the eligibility criteria, 69 studies were excluded from the review process. In vitro and animal studies have shown a potential chemopreventive effect of statins and their efficacy in adjuvant therapy of colorectal cancer. The anticarcinogenic effect on cancer risk in human studies was heterogeneous. Some studies reported better overall and cancer specific survival rates in patients using statins before and during colorectal cancer treatment. Stati...Continue Reading

Citations

Sep 21, 2019·Scientific Reports·Gemma Ibáñez-SanzVictor Moreno
Jan 8, 2020·Digestive Diseases and Sciences·Fredy Nehme
Oct 22, 2018·Biology of Sex Differences·Helena BergströmLinda Björkhem-Bergman
Nov 6, 2018·International Journal of Molecular Sciences·Michela CodiniElisabetta Albi
Oct 8, 2020·International Journal of Molecular Sciences·Masashi Maekawa, Shigeki Higashiyama
Apr 4, 2021·International Journal of Molecular Sciences·Aleksandra ZeljkovicBratislav Trifunovic

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