Statins and inflammatory bowel disease: Where do we stand?

European Journal of Internal Medicine
Spyros PeppasStefanos Bonovas

Abstract

Inflammatory bowel disease is a chronic autoimmune disorder of the western world that is rapidly expanding in newly industrialized countries. Novel strategies are urgently needed to prevent and improve the treatment of this costly and disabling disease. Statins are the most commonly prescribed drugs worldwide. Besides their lipid-lowering effects, statins may exert complex immunomodulatory properties and multiple pleiotropic effects including the inhibition of T-cell activation, antigen-presenting function and leukocyte infiltration of target organs which might render statins as beneficial agents for inflammatory and autoimmune conditions. In this review, we summarize the experimental findings on the topic, and critically appraise the epidemiological evidence regarding the value of statins as a potential strategy for preventing and treating inflammatory bowel disease. Several experimental studies have shown that statins reduce inflammation in animal models of colitis; however, clinical studies investigating their disease-modifying and preventive potential in IBD have demonstrated some limitations and conflicting results. The available epidemiological evidence is not yet sufficient to support the use of statin for preventing or ...Continue Reading

Citations

Jan 9, 2021·Cellular and Molecular Gastroenterology and Hepatology·Thergiory IrrazabalAlberto Martin
May 1, 2021·Database : the Journal of Biological Databases and Curation·Farhat KhanMandeep Kaur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Inflammatory Bowel Diseases
Justin Côté-DaigneaultJean-Frédéric Colombel
International MS Journal
Martin S WeberS S Zamvil
Journal of Controlled Release : Official Journal of the Controlled Release Society
Ahmad OryanAli Moshiri
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Rosella CiurleoSilvia Marino
© 2021 Meta ULC. All rights reserved