Statins and risk of cancer: A meta-analysis of randomized, double-blind, placebo-controlled trials

Indian Journal of Cancer
M K KimB-J Park

Abstract

Several meta-analyses of randomized controlled trials (RCTs) reported no association between the use of statins and the risk of cancer. However, they included open-label RCTs, which did not use placebo as a control group. This study aimed to evaluate the effect of statins on cancer risk using a meta-analysis of randomized, double-blind, placebo-controlled trials (RDBPCTs). We searched PubMed, EMBASE, and the Cochrane Library in March 2016. Two individual authors reviewed and selected RDBPCTs based on selection criteria. Out of 676 retrieved articles, a total of 21 RDBPCTs with 65,196 participants (32,618 in the statin group and 32,578 in the placebo group) were included in the meta-analysis. Overall, we found that there was no significant association between the use of statins and the risk of cancer (relative risk 0.97, 95% confidence interval 0.92-1.02, I2 = 0.0%) in a fixed-effect meta-analysis. In addition, in the subgroup meta-analyses, no beneficial effect of statins was observed when analyzed by statin type, country, follow-up period, methodological quality, underlying diseases/population, and type of cancer. The current meta-analysis of RDBPCTs found that there was no association between the use of statins and the risk o...Continue Reading

References

Jun 1, 1994·The American Journal of Cardiology·C D FurbergM A Espeland
Nov 15, 1993·Annals of Internal Medicine·D H BlankenhornUNKNOWN MARS Research Group
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Apr 30, 2002·Lancet·UNKNOWN LIPID Study Group (Long-term Intervention with Pravastatin in Ischaemic Disease)
Jun 22, 2002·JAMA : the Journal of the American Medical Association·Patrick W J C SerruysUNKNOWN Lescol Intervention Prevention Study (LIPS) Investigators
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 20, 2003·Lancet·Hallvard HoldaasUNKNOWN Assessment of LEscol in Renal Transplantation (ALERT) Study Investigators
Mar 2, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jennifer J KnoxAmit M Oza
Jul 15, 2005·American Journal of Epidemiology·Jackilen ShannonPaige E Farris
Jul 22, 2005·The New England Journal of Medicine·Christoph WannerUNKNOWN German Diabetes and Dialysis Study Investigators
Aug 9, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Denis E Corpet, Fabrice Pierre
Feb 24, 2006·Annals of Internal Medicine·Alan S GoUNKNOWN Atherosclerotic Disease, Vascular Function and Genetic Epidemiology (ADVANCE) Study
Sep 27, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefanos BonovasNikolaos M Sitaras
Aug 28, 2007·The American Journal of Cardiology·John C LaRosaUNKNOWN Treating to New Targets (TNT) Steering Committee and Investigators
Oct 12, 2007·The New England Journal of Medicine·Ian FordUNKNOWN West of Scotland Coronary Prevention Study Group
Apr 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Marcia L TaylorMichael J Smolak
Aug 19, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jaana KuoppalaEero Pukkala
Sep 9, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Connie B NewmanUNKNOWN Cards Investigators
Jan 17, 2009·Philosophy, Ethics, and Humanities in Medicine : PEHM·Niall ShanksJean Greek
Apr 1, 2009·The New England Journal of Medicine·Bengt C FellströmUNKNOWN AURORA Study Group
Oct 21, 2009·BMJ : British Medical Journal·Lisa HartlingTerry P Klassen
Mar 8, 2013·PloS One·Min TanChanghui Wang
May 31, 2013·Gynecologic Oncology·Ofer LavieGad Rennert
Jul 25, 2013·British Journal of Clinical Pharmacology·Xiao-long ZhangYan Wu
Nov 14, 2014·British Journal of Cancer·L BaandrupS K Kjær

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Citations

Apr 13, 2019·Cancers·Stephanie BridgemanCyril D S Mamotte
Feb 15, 2021·Current Oncology Reports·Nalinie Joharatnam-HoganRuth E Langley
Oct 17, 2020·Journal of General Internal Medicine·Sadanori OkadaYoshihiko Saito

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