Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack

Stroke; a Journal of Cerebral Circulation
David GaistL A García Rodríguez

Abstract

Although there is no overall association between statin use and intracerebral hemorrhage (ICH), whether there is an increased risk among those with a history of ischemic stroke (IS) or transient ischemic attack (TIA) remains controversial. We evaluated the relationship of preadmission statin use with the risk of ICH in patients with a history of IS or TIA in a population-based cohort. The Health Improvement Network primary care database in the United Kingdom was used to identify new users of low-dose aspirin and a matched comparison. Both cohorts were followed to identify incident cases of ICH, with validation by manual review of patient records and linkage to hospitalization data. In a nested case-control study, we compared the adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for ICH based on statin use in the subgroup of individuals with history of IS/TIA. Last statin use within 1 year of ICH (OR, 0.92; 95% CI [confidence interval], 0.60-1.4), last use between 8 days and 1 year (OR, 1.81; 95% CI, 0.99-3.28), and statin use at the time of ICH (OR, 0.77; 95% CI, 0.49-1.21) were not associated with the overall ICH risk among 157 patients with ICH and 884 controls with a history of IS/TIA. There was also no differen...Continue Reading

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Citations

Feb 12, 2019·Acta Neurologica Scandinavica·Bo-Lin HoA-Ching Chao
Jul 8, 2018·Journal of the Chinese Medical Association : JCMA·Yi-Heng LiMin-Ji Charng
Nov 28, 2019·Cardiovascular Drugs and Therapy·Veronica AzemawahMehrnoosh Hashemzadeh
Mar 3, 2020·Stroke; a Journal of Cerebral Circulation·Anette Riisgaard RibeMorten Fenger-Grøn
Dec 19, 2019·Journal of Neurology·Vasileios-Arsenios LioutasGeorgios Tsivgoulis
Apr 23, 2019·European Stroke Journal·S DebetteUNKNOWN European Stroke Science Workshop Presenters and Co-convenors

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