Statins are associated with a reduced infrarenal abdominal aortic aneurysm growth

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
O SchoutenD Poldermans

Abstract

To evaluate the effect of statins on aneurysm growth in a group of consecutive patients under surveillance for infrarenal aortic aneurysms (AAA). All patients (59 statin users, 91 non-users) under surveillance between January 2002 and August 2005 with a follow-up for aneurysm growth of at least 12 months and a minimum of three diameter evaluations were retrospectively included in the analysis. Multiple regression analysis, weighted with the number of observations, was performed to test the influence of statins on AAA growth rate. During a median period of 3.1 (1.1-13.1) years the overall mean aneurysm growth rate was 2.95+/-2.8 mm/year. Statin users had a 1.16 mm/year lower AAA growth rate compared to non-users (95% CI 0.33-1.99 mm/year). Increased age was associated with a slower growth (-0.09 mm/year per year, p = 0.003). Female gender (+1.82 mm/year, p = 0.008) and aneurysm diameter (+0.06 mm/year per mm, p = 0.049) were associated with increased AAA growth. The use of non-steroidal anti-inflammatory drugs, chronic lung disease, or other cardiovascular risk factors were not independently associated with AAA growth. Statins appear to be associated with attenuation of AAA growth, irrespective of other known factors influencing...Continue Reading

References

Jun 1, 1996·The Journal of Surgical Research·D R HolmesJ M Reilly
Jul 11, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K SinghL Bjørk
Nov 13, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·S BellostaF Bernini
Dec 5, 1998·The New England Journal of Medicine·UNKNOWN Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
May 23, 2001·Circulation·K G JonesJ T Powell
May 26, 2001·Journal of Medical Screening·UNKNOWN Chichester Aneurysm Screening GroupUNKNOWN Multicentre Aneurysm Screening Study
Sep 21, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E C VourvouriJ R Roelandt
Jan 22, 2002·Journal of Vascular Surgery·UNKNOWN Propanolol Aneurysm Trial Investigators
Mar 6, 2002·Journal of Vascular Surgery·Borhane AnnabiRichard Béliveau
Mar 29, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhaoxia LuanAndrew C Newby
Jun 24, 2004·Circulation·Anthony R BradyUNKNOWN UK Small Aneurysm Trial Participants
Jul 16, 2004·The Journal of Clinical Investigation·John A Curci, Robert W Thompson
Oct 16, 2004·The New England Journal of Medicine·Monique PrinssenUNKNOWN Dutch Randomized Endovascular Aneurysm Management (DREAM)Trial Group
Nov 9, 2004·Atherosclerosis. Supplements·T R PedersenUNKNOWN Scandinavian Simvastatin Survival Study Group
Jul 13, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·W R W WilsonM M Thompson

❮ Previous
Next ❯

Citations

Nov 3, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nader N Boushra, Muhammad Muntazar
May 25, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hiroki AokiMasunori Matsuzaki
Sep 3, 2010·Cardiovascular Drugs and Therapy·Jonathan GolledgeCatherine Rush
Feb 15, 2012·Current Treatment Options in Cardiovascular Medicine·Nicolas A Brozzi, Eric E Roselli
Nov 17, 2010·Nature Reviews. Cardiology·Ian M NordonMatt M Thompson
Feb 10, 2011·Nature Reviews. Cardiology·Ahmed KlinkZahi A Fayad
Feb 1, 2008·The New England Journal of Medicine·Roger M Greenhalgh, Janet T Powell
May 21, 2009·Cardiovascular Research·Takashi Miyake, Ryuichi Morishita
Oct 13, 2007·BMJ : British Medical Journal·Roger Greenhalgh, Janet Powell
Oct 29, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji KurosawaDai Yamanouchi
Jul 17, 2008·Vascular Health and Risk Management·Y C ChanM G Irwin
Nov 26, 2011·Journal of Neurosurgery·Serge MarbacherAndreas Raabe
Aug 5, 2014·The American Journal of Cardiology·Ryo TachikawaKazuo Chin
Jun 4, 2008·Medical & Biological Engineering & Computing·F HeldermanR Krams
Nov 26, 2009·Canadian Journal of Physiology and Pharmacology·Morris SchweitzerLorraine E Chalifour
Feb 5, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Martin J London
May 21, 2015·International Journal of Molecular Sciences·Albert M Kroon, Jan-Willem Taanman
May 21, 2015·International Journal of Molecular Sciences·Koichi YoshimuraKimikazu Hamano
May 25, 2007·Connective Tissue Research·Paul E NormanJonathan Golledge
May 19, 2012·Seminars in Vascular Surgery·Russell Samson
Oct 21, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·V B C KokjeJ H N Lindeman
Nov 10, 2009·Medical Hypotheses·M KovacevicD Vitezic
Jun 30, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Kimon BekelisNancy E Morden
Apr 29, 2008·Journal of Vascular Surgery·Felix J V SchlösserUNKNOWN SMART study group
Oct 12, 2015·International Journal of Cardiology·Joaquin De HaroFrancisco Acin
Dec 22, 2006·Annals of the New York Academy of Sciences·Christina DuftnerMichael Schirmer
Sep 8, 2012·International Journal of Vascular Medicine·Koichi Yoshimura, Hiroki Aoki
Mar 8, 2011·The British Journal of Surgery·P SandifordD Bramley
Mar 6, 2012·The British Journal of Surgery·M J SweetingUNKNOWN RESCAN collaborators
Mar 18, 2011·The British Journal of Surgery·J T PowellS G Thompson
Jan 22, 2011·The British Journal of Surgery·C P Twine, I M Williams
Dec 17, 2009·The British Journal of Surgery·A R ThompsonH Hafez
Oct 7, 2015·Journal of Diabetes and Its Complications·Kalliopi PafiliDimitri P Mikhailidis
Sep 1, 2015·The International Journal of Cardiovascular Imaging·Madelien V RegeerVictoria Delgado
Jul 14, 2010·Journal of Vascular Surgery·Andrew ThompsonHany Hafez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.