Statins everyday versus alternate days: Is there a difference in myalgia rates?

Indian Heart Journal
Ramsha RiazKaneez Fatima

Abstract

Statins are widely used drugs, known to cause myalgia, leading to high discontinuation rates. The objective of our study was to determine the frequency of myalgia in patients on everyday-dose (EDD) regimen with those on alternate-day dose (ADD) regimen. This cross sectional study was conducted in a tertiary care hospital of Pakistan. A sample size of 400 patients between the age of 40-70 years, taking simvastatin 40mg for at least 6 months or more were selected. Patients with prior musculoskeletal or neuromuscular complains, and family history of muscular disorders were excluded. Subjects were evaluated for myalgia via a self-administered questionnaire, and those complaining of myalgia were then evaluated for serum vitamin D levels. Data was analyzed through SPSS 16.0 and compared using chi square test. The overall prevalence of myalgia was 7% (28/400). Frequency of myalgia in patients taking simvastatin everyday (n=20, 10%) was significantly higher compared to those taking it every alternate day (n=8, 4%) (p=0.02). There was no significant difference between the time of onset, nature, severity, type, or location of myalgia between the 2 groups. The most common cited triggering factor for pain was physical exercise. Of the pati...Continue Reading

Citations

Feb 25, 2020·Expert Review of Clinical Pharmacology·Joseph V PergolizziPeter Magnusson
Sep 7, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·Jordon C IrwinRebecca K Vella

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Statistical Package for the Social Sciences ( SPSS )

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