Aug 25, 2009

Statins for prevention of atrial fibrillation after cardiac surgery: a systematic literature review

The Journal of Thoracic and Cardiovascular Surgery
Oliver J LiakopoulosThorsten Wahlers

Abstract

To determine the strength of evidence of preoperative statin therapy for prevention of atrial fibrillation after cardiac surgery. A meta-analysis was performed of randomized controlled trials and observational trials reporting the impact of preoperative statin therapy on the incidence of any type and new-onset atrial fibrillation after cardiac surgery. Unadjusted and adjusted treatment effects (odds ratio, 95% confidence intervals) were pooled using a random-effects model, and publication bias was assessed. Thirteen studies were identified (3 randomized controlled trials, 10 observational trials) that reported the incidence of postoperative atrial fibrillation in 17,643 patients having cardiac surgery with (n = 10,304; 58%) or without (n = 7339; 42%) preoperative statin use. New-onset atrial fibrillation was reported in a total of 7855 patients. Postoperative incidence rates for any or new-onset atrial fibrillation were 24.6% and 29.9%, respectively. Preoperative statin use resulted in a 22% and 34% unadjusted odds reduction for any atrial fibrillation (odds ratio, 0.78; 95% confidence interval, 0.67-0.90) or new-onset atrial fibrillation (odds ratio, 0.66; 95% confidence interval, 0.51-0.84) after surgery (P < .001). Relevant ...Continue Reading

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Citations

Mentioned in this Paper

Meta-Analysis (Publications)
Discipline of Heart Surgery
Anti-Arrhythmia Agents
Antiarrhythmic [EPC]
Entire Coronary Artery
Odds Ratio
Cardiac Surgery Procedures
Atrial Fibrillation
Atorvastatin
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