Statins in the chemoprevention of colorectal cancer in established animal models of sporadic and colitis-associated cancer

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Emmanouil PikoulisEfstathios Antoniou

Abstract

Despite the availability of effective surveillance for colorectal cancer with colonoscopy, chemoprevention might be an acceptable alternative. Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins have been found to be beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefits observed with statins appear to be greater than what might be expected from changes in lipid levels alone, suggesting effects beyond cholesterol lowering. This systematic review aimed to gather information on the possible chemopreventive role of statins in preventing carcinogenesis and tumor promotion by a diverse array of mechanisms in both sporadic and colitis-associated cancer in animal models. The MEDLINE database was thoroughly searched using the following keywords: 'statin, HMG-CoA reductase inhibitor, colon cancer, mice, rats, chemoprevention, colitis-associated cancer'. Additional articles were gathered and evaluated. There are a lot of clinical studies and meta-analyses, as well as a plethora of basic research studies implementing cancer cell lines and animal models, on the chemopreventive role of statins in colorectal cancer (CRC). However, data derived from clinic...Continue Reading

Citations

Feb 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanIsaac Kohane
Sep 4, 2020·World Journal of Clinical Oncology·Cristina I BarbalataAlina S Porfire
Apr 25, 2021·Breast Cancer Research and Treatment·Anjana BhardwajIsabelle Bedrosian
Jun 16, 2021·Biochemical Pharmacology·Kush K Patel, Khosrow Kashfi

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BETA
deacylation
xenografts
xenoplant

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