Statins induce regulatory T cell recruitment via a CCL1 dependent pathway

The Journal of Immunology : Official Journal of the American Association of Immunologists
Emilia MiraSantos Mañes

Abstract

The statins, a group of inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are reported to influence a variety of immune system activities through 3-hydroxy-3-methylglutaryl coenzyme A reductase-dependent and -independent mechanisms. How statin treatment regulates immune system function in vivo nonetheless remains to be fully defined. We analyzed the immunomodulatory effects of lovastatin in a Candida albicans-induced delayed-type hypersensitivity reaction in mice. In this model, lovastatin administration reduced the acute inflammatory response elicited by C. albicans challenge. This anti-inflammatory activity of lovastatin was associated with a shift from a Th1 to a Th2 immune response, as well as an increase in the percentage of regulatory T cells at the inflammation site and in the regional draining lymph node. The lovastatin-induced increase in regulatory T cells in the inflamed skin was dependent on expression of CCL1, a chemokine that is locally up-regulated by statin administration. The anti-inflammatory effect of lovastatin was abrogated in CCL1-deficient mice. These results suggest that local regulation of chemokine expression may be an important process in statin-induced modulation of the immune system.

References

Dec 2, 2000·Nature Medicine·B KwakF Mach
Jan 11, 2000·Circulation·G P van Nieuw AmerongenV W van Hinsbergh
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SebastianiA Cavani
Nov 10, 2001·Nature Immunology·R S BystryA G Betz
Aug 7, 2002·The Journal of Experimental Medicine·Francesco AnnunziatoSergio Romagnani
Dec 11, 2002·Kidney International·Luis Miguel Blanco-ColioJesús Egido
Mar 12, 2003·The Journal of Experimental Medicine·Orhan AktasFrauke Zipp
Jun 20, 2003·Nature Reviews. Drug Discovery·Jonathan A Tobert
Apr 23, 2004·Trends in Immunology·Bernhard MoserPius Loetscher
May 5, 2004·The Journal of Experimental Medicine·Patrick SchaerliBernhard Moser
Aug 18, 2004·The Journal of Experimental Medicine·Gustavo del RealSantos Mañes
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah LawmanMichael R Ehrenstein
Jan 7, 2005·The New England Journal of Medicine·Michael R EhrensteinClaudia Mauri
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel HarryJohn Greenwood
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael GombertBernhard Homey
Aug 6, 2005·Transplantation·Rosemary MastersonGavin Becker
Aug 9, 2005·The Journal of Biological Chemistry·Andrew CordleGary Landreth
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Leena ErkkiläMaija Leinonen
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon A KobashigawaLawrence Yeatman
Dec 13, 2005·Nature Reviews. Cancer·Marie-France DemierreScott M Lippman
Jan 3, 2006·Journal of Leukocyte Biology·Atilla YilmazChristoph D Garlichs
Apr 28, 2006·Nature Reviews. Immunology·John GreenwoodScott S Zamvil
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Meenakshi AroraPrabir Ray
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dulce SolerRoland Kolbeck
Dec 5, 2006·Immunology·René SchrammHans-Joachim Schäfers
Jan 2, 2007·Trends in Immunology·John Greenwood, Justin C Mason
Mar 21, 2007·The Journal of Experimental Medicine·Martin A SchneiderAntal Rot
Apr 5, 2007·JAMA : the Journal of the American Medical Association·Rajesh GuptaNeil R Powe
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose-Angel GonzaloAnthony J Coyle
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Verena MüllerMatthias Goebeler

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Citations

May 21, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Thijs K HendrikxWillem Weimar
May 25, 2010·Clinical and Experimental Immunology·K J LeeS Y Lee
Feb 5, 2010·Mucosal Immunology·A PlanagumàB D Levy
Nov 7, 2012·Seminars in Immunopathology·Aprilianto Eddy WiriaMaria Yazdanbakhsh
Nov 14, 2013·Mediators of Inflammation·David A Forero-Peña, Fredy R S Gutierrez
Nov 13, 2013·Expert Review of Anti-infective Therapy·Peter W Bergman, Linda Björkhem-Bergman
Nov 30, 2018·Nature Reviews. Immunology·Suraj P PariharFrank Brombacher
Nov 8, 2008·Nature Medicine·Raewyn Broady, Megan K Levings
Aug 20, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A J RobinsonG M Walsh
Dec 10, 2008·Nature Clinical Practice. Neurology·Nils Erik Gilhus
May 6, 2009·Seminars in Immunopathology·Fabrizio Montecucco, François Mach
Oct 23, 2010·International Journal of Dermatology·Farideh Jowkar, Mohammad Reza Namazi
Jan 31, 2012·International Forum of Allergy & Rhinology·Weihua WangDaya Upadhyay
Jun 1, 2013·Cardiovascular Drugs and Therapy·Kazuko TajiriKazutaka Aonuma
Jan 7, 2016·Frontiers in Microbiology·Elias A RahalAlexander M Abdelnoor
Feb 10, 2018·Nature Communications·Emilia MiraSantos Mañes
Aug 10, 2011·Journal of Hypertension·Andrés A HerradaAlexis M Kalergis
Jun 16, 2009·Medicinal Research Reviews·Marek Jakobisiak, Jakub Golab
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Jan 27, 2011·The Journal of Infectious Diseases·Andrew Carr
Sep 12, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ana Lucía Rodríguez-PereaPaula Andrea Velilla Hernández
Apr 15, 2017·British Journal of Pharmacology·Paul WelshPasquale Maffia
Mar 12, 2015·Journal of Immunology Research·Ana Lucía Rodríguez-PereaPaula A Velilla
Jun 14, 2017·Critical Reviews in Microbiology·Melanie PolkeIlse D Jacobsen
Aug 1, 2018·Frontiers in Immunology·Sreya BagchiChyung-Ru Wang
Jan 15, 2019·Clinical and Experimental Immunology·A L Rodríguez-PereaP A Velilla-Hernández
Nov 6, 2018·Journal of Clinical Medicine·Mona PanahiSusanne Sattler
May 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas R GelzleichterDale Stevens
Mar 31, 2015·Autoimmunity·Adriana H Tremoulet
Sep 24, 2016·The American Journal of Dermatopathology·Cynthia M MagroSebastien M de Feraudy
Apr 3, 2019·Mediators of Inflammation·Catherine PetitOlivier Huck
Mar 18, 2011·Current Opinion in Lipidology·De-xiu BuAndrew H Lichtman
Sep 20, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bennett DavenportDirk Homann
Sep 20, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens EberleinDirk Homann
Feb 1, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evgeniy EruslanovSergei Kusmartsev
Jan 21, 2021·CNS Neuroscience & Therapeutics·Huan WangXiangjian Zhang
Jun 1, 2021·Frontiers in Immunology·Xiongfeng PanAizhong Liu
Dec 18, 2009·Kidney International·Philipp EllerAlexander R Rosenkranz

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