Statins may reduce disease recurrence in patients with ulcerated primary melanoma

The British Journal of Dermatology
Lena A von SchuckmannA C Green

Abstract

Statins may restrict cellular functions required for melanoma growth and metastasis. We examined whether long-term statin use commenced before diagnosis of the primary is associated with reduced risk of melanoma recurrence. We prospectively followed a cohort of patients newly diagnosed between 2010 and 2014 with localised tumour-stage T1b to T4b melanoma in Queensland, Australia. We used Cox-regression analyses to examine associations between long-term statin use and melanoma recurrence for the entire cohort, and then separately by sex and by presence of ulceration due to evidence of effect modification. Amongst 700 patients diagnosed with stage T1b to T4b primary melanoma (mean age 62, 59% male, 28% with ulcerated tumours), 94 patients (13%) developed melanoma recurrence within 2 years. Long-term statin users (n=204, 29%) had a significantly lower risk of disease recurrence compared to non-users (Adjusted hazard ratio (HRadj ) 0.55, 95% Confidence Interval (CI) 0.32-0.97) regardless of statin subtype or potency. Compared to non-statin users, risk of recurrence was significantly decreased in male statin-users (HRadj 0.39, 95% CI 0.19-0.79) but not female statin users (HRadj 0.82, 95% CI 0.29-2.27) and in statin-users with ulcer...Continue Reading

References

Dec 2, 2000·Nature Medicine·B KwakF Mach
Apr 6, 2002·Circulation Research·Carmen UrbichStefanie Dimmeler
Jun 29, 2004·Journal of Surgical Oncology·Ulrike LeiterClaus Garbe
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
Apr 9, 2005·Human Reproduction Update·Annechien BoumanMarijke M Faas
Apr 6, 2006·Journal of the National Cancer Institute·Véronique WinnepenninckxUNKNOWN Melanoma Group of the European Organization for Research and Treatment of Cancer
Oct 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E R KoomenH J Guchelaar
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Apr 17, 2009·Pigment Cell & Melanoma Research·Vladislava O Melnikova, Menashe Bar-Eli
Jun 11, 2009·Current Cancer Drug Targets·G Fritz
Apr 10, 2010·Expert Opinion on Drug Safety·Denise M BoudreauJeanene Johnson
Dec 18, 2010·Lipids in Health and Disease·Giovani M FaveroSergio P Bydlowski
Mar 14, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adèle C GreenMark Smithers
Jul 31, 2012·Nature Genetics·Michael KrauthammerRuth Halaban
Nov 9, 2012·The New England Journal of Medicine·Sune F NielsenStig E Bojesen
Mar 16, 2013·Frontiers in Immunology·Christine PichAnne-Françoise Tilkin-Mariamé
Oct 9, 2013·International Journal of Oncology·Mario ZanfardinoFranco Morelli
Sep 16, 2014·Pigment Cell & Melanoma Research·Rosalyn JewellJulia Newton-Bishop
Dec 3, 2014·American Journal of Preventive Medicine·Gery P GuyK Robin Yabroff
Sep 9, 2016·Postȩpy dermatologii i alergologii·Malgorzata MajTomasz Drewa
Nov 14, 2016·JAMA : the Journal of the American Medical Association·Roger ChouThomas L Jeanne
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Zubing MeiWei Yang
Apr 4, 2017·The British Journal of Dermatology·C KarimkhaniC Fitzmaurice
Aug 27, 2017·The Journal of Investigative Dermatology·Lena A von SchuckmannAdele C Green
Oct 14, 2017·CA: a Cancer Journal for Clinicians·Jeffrey E GershenwaldUNKNOWN for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Disc
May 21, 2018·The Lancet Oncology·Fabio ConfortiAron Goldhirsch

❮ Previous
Next ❯

Citations

Oct 31, 2020·Cancers·Laurence PellerinNathalie Andrieu-Abadie
Aug 20, 2020·Seminars in Cancer Biology·Amir R AfshariAmirhossein Sahebkar
Nov 10, 2021·Journal of Proteome Research·Xu-Dong WangYonghao Yu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Investigative Dermatology
Lena A von SchuckmannAdèle Green
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Claudia C RamirezRobert S Kirsner
The Journal of Investigative Dermatology
Victor SiskindD C Whiteman
© 2021 Meta ULC. All rights reserved