Abstract
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Chronic hepatitis B (HBV) and C virus (HCV) infection causes liver cancer. This protocol is to provide the methods used to assess the relationship between statins and HCC risk in hepatitis B or C patients. We will search comprehensively the PubMed (medline), Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure, Wanfang Database from their inception to November 2017. We will include studies that evaluated and clearly defined exposure to statins, reported the HCC incidence in hepatitis B/C patients or HBV/HCV-related cirrhosis patients, provided effective comparison groups, and reported risk estimates, such as hazard ratios, relative risks, or odds ratios with corresponding 95% confidence intervals or sufficient data for their estimation. We will use Stata (version 15.0) to compute the data synthesis carefully when a meta-analysis is allowed. This study will provide a high-quality synthesis of current evidence of statins on HCC risk in hepatitis B or C patients. The conclusion of our systematic review will provide evidence to judge whether statin is an effective intervention for hepatitis B or C patients.
References
May 21, 2010·Journal of Hepatology·George V PapatheodoridisAnna Lok
Jul 24, 2010·European Journal of Epidemiology·Andreas Stang
Dec 16, 2010·The American Journal of Gastroenterology·Hui-Fen ChiuChun-Yuh Yang
Jan 26, 2012·Vaccine·J J OttS T Wiersma
Oct 16, 2012·Gastroenterology·Siddharth SinghWilliam Sanchez
Nov 23, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khayriyyah Mohd HanafiahSteven T Wiersma
Sep 18, 2014·BMJ Open·Meng ShiXiaobing Cui
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Feb 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwin N AnanthakrishnanIsaac Kohane
Nov 25, 2016·Current Medical Research and Opinion·Lai Wei, Jia-Horng Kao
Mar 16, 2017·BMC Medicine·Thomas F BaumertYujin Hoshida
Mar 25, 2017·Journal of Hepatology·Paola BertuccioEva Negri
Oct 11, 2017·Journal of Hepatology·Naoto FujiwaraYujin Hoshida
Feb 7, 2018·International Journal of Cancer. Journal International Du Cancer·David E DaweSalaheddin M Mahmud
Apr 3, 2018·Journal of Clinical and Translational Hepatology·Page AxleyAshwani K Singal