Stationarity in neuromonitoring data

Acta Neurochirurgica. Supplement
Hans E HeisslerEckhard Rickels

Abstract

Signals reflecting the metabolic and circulatory status of an injured central nervous system are normally corrupted systematically. The patient is part of a therapeutic control-loop and the signals acquired are rather determined by the quality of control (stationarity of signals) than by the underlying pathological process. To verify the control-loop hypothesis, neuromonitoring data from 12 randomly selected severely head injured patients (initial GCS ≤ 8, 7 men, 5 women) were analysed for circulatory (blood pressure, intracranial pressure [ICP], cerebral perfusion pressure [CPP]) and metabolic (arterial blood gases, jugular bulb oxygenation [SjvO(2)], brain tissue oxygen partial pressure [ptiO(2)]) variables (n = 10). A total of 120 time series of generally not equidistant sample intervals were assessed for stationarity by Wallis & Moore's runs test. Non-stationarity could only be proven in 23 time series, i.e. the control-loop hypothesis was violated. Trends were mainly found in CPP (n = 5) and ICP (n = 4). The remaining cases spread out on all but one (temperature) signal. Nine patients showed at least one time series with a trend. One patient had clear trends in five out of ten variables that focused on SjvO(2), ptiO(2), IC...Continue Reading

Citations

Jul 11, 2018·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·María GarcíaRoberto Hornero

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