Statistical analysis of gait rhythm in patients with Parkinson's disease

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Yunfeng Wu, Sridhar Krishnan

Abstract

To assess the gait variability in patients with Parkinson's disease (PD), we first used the nonparametric Parzen-window method to estimate the probability density functions (PDFs) of stride interval and its two subphases (i.e., swing interval and stance interval). The gait rhythm standard deviation (sigma) parameters computed with the PDFs indicated that the gait variability is significantly increased in PD. Signal turns count (STC) was also derived from each outlier-processed gait rhythm time series to serve as a dominant feature, which could be used to characterize the gait variability in PD. Since it was observed that the statistical parameters of swing interval or stance interval were highly correlated with those of stride interval, this article only used the stride interval parameters, i.e., sigma(r) and STC(r) , to form the feature vector in the pattern classification experiments. The results evaluated with the leave-one-out cross-validation method demonstrated that the least squares support vector machine with polynomial kernels was able to provide a classification accurate rate of 90.32% and an area (Az) of 0.952 under the receiver operating characteristic curve, both of which were better than the results obtained with ...Continue Reading

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Citations

Oct 31, 2014·Journal of Medical Systems·Abed Khorasani, Mohammad Reza Daliri
Mar 25, 2014·IEEE Transactions on Bio-medical Engineering·Delaram JarchiGuang-Zhong Yang
Nov 10, 2015·IEEE Journal of Biomedical and Health Informatics·Ferdous WahidDavid C Ackland
Apr 11, 2013·Computational and Mathematical Methods in Medicine·Suxian CaiSridhar Krishnan
Apr 2, 2016·Computational and Mathematical Methods in Medicine·Yi XiaDexiang Zhang
Jul 31, 2014·Computer Methods in Biomechanics and Biomedical Engineering·C Corbier, M El Badaoui
Sep 12, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Delaram JarchiGuang-Zhong Yang
May 30, 2012·Surgical Innovation·Louis AtallahGuang-Zhong Yang
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Jan 13, 2019·Sensors·Nicolas KhourySamer Mohammed
Oct 27, 2018·Computational and Mathematical Methods in Medicine·Qiang YeZhiming Yao
Mar 17, 2019·Medical Engineering & Physics·Murtadha D HssayeniBehnaz Ghoraani
Mar 19, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Ahmed HalimMostafa R A Atia
Oct 16, 2021·Brain Informatics·Tuan D Pham

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