PMID: 7022455Jun 1, 1981Paper

Statistical analysis of the Ames Salmonella/microsome test

Proceedings of the National Academy of Sciences of the United States of America
B H MargolinE Zeiger

Abstract

A family of statistical models for analysis of Ames Salmonella/microsome test data is constructed that considers mutation and toxicity as competing risks and allows hyper-Poisson variability. These models have a parameter than can be employed as a mutagenic index because it approximates the slope at zero dose of a dose-response curve adjusted for toxicity. A second parameter quantifies plate-to-plate variability and lends itself to the study of factors affecting internal test reproducibility. The detection of aberrant plate counts is also addressed. This methodology is illustrated with data from a Salmonella test.

Citations

Jan 1, 1997·Environmental and Molecular Mutagenesis·B A FettermanE Zeiger
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Jan 1, 1994·Environmental Health Perspectives·B H MargolinE Zeiger

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