Statistical analysis of wound-healing rates for pressure ulcers

American Journal of Surgery
Sylvan Wallenstein, Harold Brem

Abstract

To establish a functional model for determining wound-healing rates to use in the evaluation of efficacy of wound therapies, a review was conducted of statistical analysis methods from past wound-healing studies. Because most wounds do not usually close within the period of observation, that is, 12 weeks, evaluating time to 100% closure is not practical. Thus, a new, practical model for statistical analysis was formulated. A Gompertz-like function was applied to wound-healing rates of pressure ulcers, in the context of repeated measures for a nonlinear model. Photographing the wounds weekly, tracing their area with planimetry, and applying this new statistical model allows for the calculation of the expected rate of healing as a function of time. This approach yields a model useful for identifying prognostic factors, evaluating treatments, and improving our understanding of the variables that affect the wound-healing process.

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Citations

Apr 2, 2009·BMC Dermatology·Matthew CardinalDavid G Armstrong
Jan 24, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Matthew CardinalKeith Harding
Feb 9, 2012·International Wound Journal·Ewald AmbrózyMichael E Gschwandtner
Oct 24, 2014·PloS One·Fernando Jose AntonioRenio dos Santos Mendes
Mar 7, 2019·Journal of Wound Care·Emily HaeslerKeryln Carville
Jul 15, 2017·Pain·Timothy T HouleJames C Eisenach
Mar 2, 2019·International Wound Journal·David A JenkinsSabine N van der Veer
Sep 30, 2006·International Wound Journal·Keith MooreKeith G Harding
Aug 11, 2021·International Wound Journal·Richard Hillson BullKeith Gordon Harding

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