PMID: 8582354Sep 1, 1995Paper

Statistical and genetic aspects of quality control for DNA identification

Electrophoresis
N E Morton, A E Collins

Abstract

Quality control for likelihood ratio (LR) tests on restriction fragment length polymorphisms (RFLPs) and polymerase chain reaction (PCR) markers is provided by the 4N6 program. Examples are given for test of exclusion, coincidence, and kinship that should be used routinely in validation of DNA profiling. They confirm that "in a knowledgeable court DNA profiling is no longer exposed to risk of illogical presentation, blind acceptance or arbitrary rejection" (N. E. Morton, Eur. J. Hum. Genet. 1993, 1, 172-179). However, they remain to be implemented in national systems of quality control. There can be no effective quality control until attempts to fudge gene frequencies in order to retain the Hardy-Weinberg assumption (recommended by the National Research Council) ar abandoned in favour of the population genetic approach that takes gene frequencies from a real population and uses kinship to express genotype probabilities. Since an expert witness cannot know the identity of the culprit, he is obliged to consider multiple hypothesis without usurping the prerogative of the court to favour one of them on the basis of other evidence. It remains to be seen whether the new NRC Committee (and more importantly the international community ...Continue Reading

References

Oct 1, 1992·Nature Genetics·C GintherM C King
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N E Morton
Apr 17, 1992·Science·L Roberts
Dec 20, 1991·Science·R C Lewontin, D L Hartl
Nov 21, 1991·Nature·A J JeffreysD G Monckton
Jul 1, 1966·Vox Sanguinis·M P Mi, N E Morton
Jan 1, 1995·Genetica·N E Morton
Oct 27, 1994·Nature·E S Lander, B Budowle
Nov 1, 1994·Nature Genetics
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Collins, N E Morton
Jan 1, 1993·European Journal of Human Genetics : EJHG·N E Morton
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N E MortonI Balazs

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Citations

Aug 28, 2001·Journal of Chromatography. a·C BartaA Guttman
Nov 24, 2005·Nature Reviews. Genetics·François PompanonPierre Taberlet

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