Statistical and mechanistic approaches to understanding the gas-phase fragmentation behavior of methionine sulfoxide containing peptides

Journal of Proteome Research
Gavin E ReidRichard I Simpson

Abstract

Recently, we carried out a statistical analysis of a 'tryptic' peptide tandem mass spectrometry database in order to identify sequence-dependent patterns for the gas-phase fragmentation behavior of protonated peptide ions, and to improve the models for peptide fragmentation currently incorporated into peptide sequencing and database search algorithms [Kapp, E. A., Schutz, F., Reid, G. E., Eddes, J. S., Moritz, R. L., O'Hair, R. A. J., Speed, T. P. and Simpson, R. J. Anal. Chem. 2003, 75, 6251-6264.]. Here, we have reexamined this database in order to determine the effect of a common post-translational or process induced modification, methionine oxidation, on the appearance and relative abundances of the product ions formed by low energy collision induced dissociation of peptide ions containing this modification. The results from this study indicate that the structurally diagnostic neutral loss of methane sulfenic acid (CH3SOH, 64Da) from the side chain of methionine sulfoxide residues is the dominant fragmentation process for methionine sulfoxide containing peptide ions under conditions of low proton mobility, i.e., when ionizing proton(s) are sequestered at strongly basic amino acids such as arginine, lysine or histidine. The ...Continue Reading

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Citations

Jun 1, 2005·Journal of the American Society for Mass Spectrometry·Gavin E ReidRichard A J O'Hair
Aug 29, 2006·Journal of the American Society for Mass Spectrometry·Mahasilu AmunugamaGavin E Reid
Nov 28, 2006·Journal of the American Society for Mass Spectrometry·Saiful M ChowdhuryJames E Bruce
Dec 13, 2006·Journal of the American Society for Mass Spectrometry·Juma D BridgewaterRichard W Vachet
Jun 23, 2007·Journal of the American Society for Mass Spectrometry·R SrikanthRichard W Vachet
Aug 11, 2007·Journal of the American Society for Mass Spectrometry·Jennifer M Froelich, Gavin E Reid
Nov 22, 2013·Environmental Science & Technology·Lisa A D'Agostino, Scott A Mabury
Apr 5, 2007·Nature Protocols·David L TabbAmy-Joan L Ham
Sep 5, 2009·Science·Roberto VanacoreBilly G Hudson
Mar 29, 2014·Journal of the American Society for Mass Spectrometry·Alice L Pilo, Scott A McLuckey
Oct 5, 2014·Journal of the American Society for Mass Spectrometry·Bing WangWei Kong
Jul 18, 2014·Analytical Chemistry·Nai-ping DongWei Fan
Sep 23, 2008·Journal of Inorganic Biochemistry·Yuan-Han ChenMichael J Knapp
Aug 18, 2005·Rapid Communications in Mass Spectrometry : RCM·V Vaz SerraA J Ferrer-Correia
Aug 29, 2009·Rapid Communications in Mass Spectrometry : RCM·Linda FeketeováRichard A J O'Hair
Jan 23, 2009·Journal of Mass Spectrometry : JMS·Rapole SrikanthRichard W Vachet
Jul 25, 2006·Rapid Communications in Mass Spectrometry : RCM·Florian Wolschin, Wolfram Weckwerth
Mar 3, 2007·Rapid Communications in Mass Spectrometry : RCM·James SierakowskiGavin E Reid
Aug 27, 2010·Rapid Communications in Mass Spectrometry : RCM·Adrian K Y LamRichard A J O'Hair
Jul 25, 2014·Free Radical Biology & Medicine·Shen LuoEmily Shacter
Sep 25, 2012·Journal of Proteome Research·Annette MichalskiMatthias Mann
Nov 4, 2016·Journal of Mass Spectrometry : JMS·Bing WangXinhua Guo
Feb 9, 2017·Journal of Proteome Research·Wiebke Maria NadlerChristoph Rösli
Jun 7, 2018·Rapid Communications in Mass Spectrometry : RCM·Nick Degraan-WeberJames P Reilly
Jan 29, 2021·Molecular Omics·Hester A BeardSteven H L Verhelst

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