Statistical characterisation of bacterial wild-type MIC value distributions and the determination of epidemiological cut-off values

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
J TurnidgeG Kronvall

Abstract

MIC distribution data were obtained from a variety of international sources, and pooled after selection by a defined criterion. Sixty-seven of these datasets were subjected to a range of statistical goodness-of-fit tests. The log-normal distribution was selected for subsequent modelling. Cumulative counts of MIC distribution data were fitted to the cumulative log-normal distribution using non-linear least squares regression for a range of data subsets from each antibiotic-bacterium combination. Estimated parameters in the regression were the number of isolates in the subset, and (the log(2) values of) the mean and standard deviation. Optimum fits for the cumulative log-normal curve were then used to determine the wild-type MIC range, determined by calculating the MICs associated with the lower and upper 0.1% of the distribution, rounding to the nearest two-fold dilution, and calculating the probabilities of values higher and lower than these values. When plotted logarithmically, histograms of MIC frequencies appeared normal (Gaussian), but standard goodness-of-fit tests showed that the two-fold dilution grouping of MICs fits poorly to a log-normal distribution, whereas non-linear regression gave good fits to population (histogr...Continue Reading

References

Feb 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G KronvallM F Galas
Jul 3, 2003·The Journal of Antimicrobial Chemotherapy·Gunnar KahlmeterAlkiviadis Vatopoulos

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Citations

Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John D Turnidge, UNKNOWN Subcommittee on Antimicrobial Susceptibility Testing of the Clinical and Laboratory Standards Institute
Oct 30, 2012·The Journal of Antimicrobial Chemotherapy·Ines MouraPaola Mastrantonio
Apr 7, 2010·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraMichael A Pfaller
Apr 13, 2007·Clinical Microbiology Reviews·Stephen TristramPeter C Appelbaum
Jul 17, 2007·Clinical Microbiology Reviews·John Turnidge, David L Paterson
Aug 21, 2009·Journal of Clinical Microbiology·M A PfallerUNKNOWN Clinical and Laboratory Standards Institute Antifungal Testing Subcommittee
Jun 21, 2013·Journal of Clinical Microbiology·Haihong HaoZonghui Yuan
Apr 30, 2011·Future Microbiology·David S Perlin
Oct 16, 2013·Antimicrobial Agents and Chemotherapy·Mariana CastanheiraMichael A Pfaller
Feb 7, 2016·The Journal of Antimicrobial Chemotherapy·Anne-Marie Van den AbeeleKurt Houf
Mar 19, 2013·Revista iberoamericana de micología·Antonella Souza MatteiLuiz Carlos Severo
Apr 13, 2012·Diagnostic Microbiology and Infectious Disease·Shawn R LockhartUNKNOWN Cryptococcus gattii PNW Public Health Working Group
Apr 13, 2010·Enfermedades infecciosas y microbiología clínica·Rafael Cantón
Dec 9, 2008·Veterinary Microbiology·Björn BengtssonKarin Persson Waller
Oct 3, 2015·Diagnostic Microbiology and Infectious Disease·Shawn R LockhartAngela A Cleveland
Apr 5, 2013·Pharmacotherapy·Gregory A Eschenauer, Peggy L Carver
Aug 16, 2013·Statistics in Medicine·Stijn JaspersPierre-Alexandre Beloeil

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