Statistical design and analysis in trials of proportionate interventions: a systematic review

Trials
Jane CandlishTracey Bywater

Abstract

In proportionate or adaptive interventions, the dose or intensity can be adjusted based on individual need at predefined decision stages during the delivery of the intervention. The development of such interventions may require an evaluation of the effectiveness of the individual stages in addition to the whole intervention. However, evaluating individual stages of an intervention has various challenges, particularly the statistical design and analysis. This review aimed to identify the use of trials of proportionate interventions and how they are being designed and analysed in current practice. We searched MEDLINE, Web of Science and PsycINFO for articles published between 2010 and 2015 inclusive. We considered trials of proportionate interventions in all fields of research. For each trial, its aims, design and analysis were extracted. The data synthesis was conducted using summary statistics and a narrative format. Our review identified 44 proportionate intervention trials, comprising 28 trial results, 13 protocols and three secondary analyses. These were mostly described as stepped care (n=37) and mainly focussed on mental health research (n=30). The other studies were aimed at finding an optimal adaptive treatment strategy ...Continue Reading

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Citations

Feb 11, 2020·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Ben KelceyYanli Xie
Sep 1, 2021·European Journal of Sport Science·M Pinto-CarbóA Molina-Barceló

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