Statistical determinants of dendritic morphology in hippocampal pyramidal neurons: A hidden Markov model

Hippocampus
Alexei V Samsonovich, Giorgio A Ascoli

Abstract

Dendritic structure is traditionally characterized by distributions and interrelations of morphometric parameters, such as Sholl-like plots of the number of branches versus dendritic path distance. However, how much of a given morphology is effectively captured by any statistical description is generally unknown. In this work, we assemble a small number of standard geometrical parameters measured from experimental data in a simple stochastic algorithm to describe the dendrograms of hippocampal pyramidal cells. The model, consistent with the hidden Markov framework, is feedforward, local, and causal. It relies on two "hidden" local variables: the expected number of terminal tips in a given subtree, and the current path distance from the soma. The algorithm generates dendrograms that statistically reproduce all morphological essentials of dendrites observed in real neurons, including the distributions of branching and termination points, branch lengths, membrane area, topological asymmetry, and (assuming passive membrane parameters within physiological range) electrotonic characteristics. Thus, this algorithm and the small number of its morphometric parameters constitute a remarkably complete description of the dendrograms of hip...Continue Reading

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Citations

Sep 1, 2005·Journal of Computational Neuroscience·Duncan E Donohue, Giorgio A Ascoli
May 2, 2006·Journal of Computational Neuroscience·Bruce P GrahamDouglas R Mclean
Feb 9, 2012·Journal of Computational Neuroscience·Daniela BianchiMichele Migliore
Sep 18, 2008·Neuroinformatics·Benjamin Torben-NielsenEric O Postma
Aug 21, 2013·Journal of Neuroscience Methods·Cesar Henrique Comin, Luciano da Fontoura Costa
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Quan WenDmitri B Chklovskii
Apr 13, 2007·Journal of Neurophysiology·Klaus M Stiefel, Terrence J Sejnowski
Nov 23, 2006·BMC Neuroscience·Bruce P Graham, Arjen van Ooyen
Nov 21, 2007·PLoS Computational Biology·Kaoru SugimuraAtsushi Mochizuki
May 17, 2008·PLoS Computational Biology·Duncan E Donohue, Giorgio A Ascoli
Feb 8, 2011·Journal of Theoretical Biology·Ronald A J van Elburg
Dec 2, 2010·Brain Research Reviews·Duncan E Donohue, Giorgio A Ascoli
Jun 15, 2007·The Journal of Comparative Neurology·William B Marks, Robert E Burke
Jul 2, 2010·The Journal of Comparative Neurology·Reza ZomorrodiIgor Timofeev
Aug 6, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Christopher G LanghammerBonnie L Firestein
May 13, 2006·Journal of Neuroscience Methods·Artur Luczak
Mar 23, 2006·Nature Reviews. Neuroscience·Giorgio A Ascoli
Feb 29, 2008·Journal of Neurophysiology·Quan Wen, Dmitri B Chklovskii
Nov 3, 2017·Brain Structure & Function·Sumit NandaGiorgio A Ascoli
Apr 5, 2018·Scientific Reports·Eliedonna CacaoFrancis A Cucinotta
Oct 26, 2018·Scientific Reports·Congping LinYiwei Zhang

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