Statistical indices for simultaneous large-scale metabolite detections for a single NMR spectrum

Analytical Chemistry
Eisuke ChikayamaJun Kikuchi

Abstract

NMR-based metabolomics has become a practical and analytical methodology for discovering novel genes, biomarkers, metabolic phenotypes, and dynamic cell behaviors in organisms. Recent developments in NMR-based metabolomics, however, have not concentrated on improvements of comprehensiveness in terms of simultaneous large-scale metabolite detections. To resolve this, we have devised and implemented a statistical index, the SpinAssign p-value, in NMR-based metabolomics for large-scale metabolite annotation and publicized this information. It enables simultaneous annotation of more than 200 candidate metabolites from the single (13)C-HSQC (heteronuclear single quantum coherence) NMR spectrum of a single sample of cell extract.

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Aug 19, 2011·Analytical Chemistry·Kerem Bingol, Rafael Brüschweiler
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Jan 31, 2019·Bioscience, Biotechnology, and Biochemistry·Noriko KanaiIzuru Kawamura

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