Apr 28, 2020

Altered sensory neuron development in CMT2D mice is site-specific and linked to increased GlyRS levels

BioRxiv : the Preprint Server for Biology
James N SleighG. Schiavo

Abstract

Dominant, missense mutations in the widely and constitutively expressed GARS1 gene cause a peripheral neuropathy that usually begins in adolescence and principally impacts the upper limbs. Caused by a toxic gain-of-function in the encoded glycyl-tRNA synthetase (GlyRS) enzyme, the neuropathology appears to be independent of the canonical role of GlyRS in aminoacylation. Patients display progressive, life-long weakness and wasting of muscles in hands followed by feet, with frequently associated deficits in sensation. When dysfunction is observed in motor and sensory nerves, there is a diagnosis of Charcot-Marie-Tooth disease type 2D (CMT2D), or distal hereditary motor neuropathy type V if the symptoms are purely motor. The cause of this varied sensory involvement remains unresolved, as are the pathomechanisms underlying the selective neurodegeneration characteristic of the disease. We have previously identified in CMT2D mice that neuropathy-causing Gars mutations perturb sensory neuron fate and permit mutant GlyRS to aberrantly interact with neurotrophin receptors (Trks). Here, we extend this work by interrogating further the anatomy and function of the CMT2D sensory nervous system in mutant Gars mice, obtaining several key resu...Continue Reading

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Mentioned in this Paper

United States Food and Drug Administration
Immune Response
Immune System
Whole Blood
Sequence Determinations, RNA
Vaccines
Influenza virus vaccine
Abr protein, mouse
Bio-Informatics
Statistical Test

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