Statistical issues in a metaregression analysis of randomized trials: impact on the dietary sodium intake and blood pressure relationship

Biometrics
C M GreenwoodA G Logan

Abstract

In a meta-analysis of randomized trials of the effects of dietary sodium interventions on blood pressure, we found substantial heterogeneity among the studies. We were interested in evaluating whether measurement error, known to be a problem for dietary sodium measures, publication bias, or confounding factors could be responsible for the heterogeneity. A measurement error correction was developed that corrects both the slope and the intercept and takes into account the sample size of each study and the number of measurements taken on an individual. The measurement error correction had a minimal effect on the estimates, although it performed well in simulated data. A smoothed scatter plot was used to assess publication bias. Metaregressions provide a convenient way to jointly assess the effects of several factors, but care must be taken to fit an appropriate model.

References

Apr 1, 1992·American Journal of Hypertension·M Muntzel, T Drüeke
Jul 1, 1992·Journal of Clinical Epidemiology·D FollmannJ Cutler
Nov 1, 1991·Statistics in Medicine·A Whitehead, J Whitehead
Jan 1, 1987·Epidemiologic Reviews·S Greenland
Aug 1, 1994·American Journal of Epidemiology·S Greenland
Jan 1, 1993·Statistical Methods in Medical Research·J L Fleiss
May 22, 1996·JAMA : the Journal of the American Medical Association·J P MidgleyA G Logan
Sep 21, 1996·BMJ : British Medical Journal·S J SharpD G Altman

❮ Previous
Next ❯

Citations

Jul 12, 2002·Statistics in Medicine·Simon G Thompson, Julian P T Higgins
Aug 10, 2007·Current Hypertension Reports·Daniel T Lackland, Brent M Egan
Aug 9, 2005·Journal of Clinical Epidemiology·Norma TerrinJoseph Lau
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shreyasee AminDavid T Felson
Aug 13, 2002·Journal of Hypertension·Johanna M GeleijnseFrans J Kok
Feb 4, 2016·Statistics in Medicine·Getachew A DagneLei Liu
May 3, 2011·Journal of Clinical Epidemiology·Santiago G MorenoKeith R Abrams
Nov 30, 2004·Statistics in Medicine·Ammarin ThakkinstianJohn Attia
Jun 24, 2003·Statistics in Medicine·Norma TerrinIngram Olkin
Jan 24, 2007·Health Economics·Marin C GemmillAlistair McGuire
Feb 22, 2008·Paediatric and Perinatal Epidemiology·Hairong XuWilliam D Fraser
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Johannes C van der WoudenFrancine Ducharme
Aug 16, 2019·Circulation. Cardiovascular Quality and Outcomes·Toshiaki ToyotaTakeshi Kimura
Jan 5, 2002·Statistical Methods in Medical Research·S G ThompsonD E Warn
Mar 14, 2019·International Journal of Rheumatology·John A CuencaLeonardo Tamariz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.