Statistical learning of origin-specific statically optimal individualized treatment rules.

The International Journal of Biostatistics
Mark J van der Laan, Maya L Petersen

Abstract

Consider a longitudinal observational or controlled study in which one collects chronological data over time on a random sample of subjects. The time-dependent process one observes on each subject contains time-dependent covariates, time-dependent treatment actions, and an outcome process or single final outcome of interest. A statically optimal individualized treatment rule (as introduced in van der Laan et. al. (2005), Petersen et. al. (2007)) is a treatment rule which at any point in time conditions on a user-supplied subset of the past, computes the future static treatment regimen that maximizes a (conditional) mean future outcome of interest, and applies the first treatment action of the latter regimen. In particular, Petersen et. al. (2007) clarified that, in order to be statically optimal, an individualized treatment rule should not depend on the observed treatment mechanism. Petersen et. al. (2007) further developed estimators of statically optimal individualized treatment rules based on a past capturing all confounding of past treatment history on outcome. In practice, however, one typically wishes to find individualized treatment rules responding to a user-supplied subset of the complete observed history, which may no...Continue Reading

References

Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Apr 14, 2006·Basic & Clinical Pharmacology & Toxicology·Miguel A HernánJames M Robins

❮ Previous
Next ❯

Citations

Oct 10, 2009·Biometrical Journal. Biometrische Zeitschrift·Erica E M Moodie
Jun 9, 2018·The International Journal of Biostatistics·Wenjing ZhengMark J van der Laan
Nov 18, 2014·Annual Review of Statistics and Its Application·Bibhas Chakraborty, Susan A Murphy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.