PMID: 9533262Apr 9, 1998Paper

Statistical methods for population pharmacokinetic modelling

Statistical Methods in Medical Research
A Racine-Poon, J Wakefield

Abstract

A principal aim of population pharmacokinetic studies is to estimate the variance components associated with intra- and inter-individual variability in observed drug concentrations. The explanation of the inter-individual variability in terms of subject-specific covariates is also of great importance. Pharmacokinetic models are nonlinear in the parameters and estimation is not straightforward. Within this paper we review a number of estimation approaches which have been suggested for population pharmacokinetic analyses. We distinguish between Bayesian and non-Bayesian and fully-parametric, semi-parametric and nonparametric methods.

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Citations

Jan 15, 2000·Statistical Methods in Medical Research·L Sheiner, J Wakefield
Oct 14, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Christoffer W TornøeE Niclas Jonsson
May 17, 2008·European Journal of Clinical Pharmacology·Kayode Ogungbenro, Leon Aarons
May 8, 2001·Statistical Methods in Medical Research·G M Raab, T Parpia
Apr 10, 2013·Journal of Diabetes Science and Technology·Anne Katrine Duun-HenriksenHenrik Madsen
Jan 15, 2000·Statistical Methods in Medical Research·S G MachadoC Hu
Jun 25, 2005·Statistics in Medicine·Kim E Andersen, Malene Højbjerre
Mar 10, 2010·Nature Reviews. Genetics·Duncan Thomas
Sep 22, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Rune V OvergaardHenrik Madsen

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