Statistical methods for the analysis of genetic association studies

Annals of Human Genetics
G Y Zou

Abstract

This paper applies a retrospective logistic regression model (Prentice, 1976) using a sandwich variance estimator (White, 1982; Zeger et al. 1985) to genetic association studies in which alleles are treated as dependent variables. The validity of switching the positions of allele and trait variables in the regression model is ensured by the invariance property of the odds ratio. The approach is shown to be able to accommodate many commonly seen designs, matched or unmatched alike, having either binary or quantitative traits. The resultant score statistic has potentially higher power than those that have previously appeared in the genetics literature. As a regression model in general, this approach may also be applied to incorporate covariates. Numerical examples implemented with standard software are presented.

Citations

Jul 8, 2011·The British Journal of Nutrition·Xiao Hong DuYong Min Xiong
Mar 29, 2007·Annals of Human Genetics·Yik Y TeoMark Seielstad
Mar 22, 2008·Annals of Human Genetics·M GuedjB Prum
May 29, 2008·Annual Review of Genomics and Human Genetics·B S Weir
May 24, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Oliver Mayo
May 13, 2015·The American Journal of Gastroenterology·Habeeb SalamehAshwani K Singal
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·James H FowlerNicholas A Christakis
Oct 21, 2009·Genetic Testing and Molecular Biomarkers·Rupak MukhopadhyayPradeep K Ghosh
Jun 6, 2007·Genetic Epidemiology·Gang ZhengNancy L Geller
Mar 18, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Grzegorz ZalewskiLech Chyczewski
Feb 4, 2009·European Journal of Epidemiology·Julian LittleNick Birkett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.