Statistical methods used in the calculation of geriatric reference intervals: a systematic review

Clinical Chemistry and Laboratory Medicine : CCLM
Erika Arseneau, Cynthia M Balion

Abstract

Geriatric reference intervals (RIs) are not commonly available and are rarely used. It is difficult to select a reference population from a cohort with a high degree of morbidity. Also important are the statistical approaches used to determine health-associated reference values. It is the aim of this study to examine the statistical methods used in the calculation of geriatric RIs. A search was conducted on EMBASE and Medline for articles between January 1989 and January 2014. Studies were selected if they: 1) were English primary articles; 2) performed a clinical chemistry test on a blood fraction; 3) had a population sub-group consisting of individuals ≥65 years of age; and 4) calculated a RI for the subgroup ≥65 years of age. There were 64 articles identified, of which 78.1% described the RI calculation method used. RI calculation was performed by non-parametric (21.9%), parametric (42.2%), robust (3.1%), or other (17.2%) methods. Outlier detection (SD, Grubb's test, Tukey's fence, Dixon) was infrequently used and although most studies performed partitioning, only 57.8% tested the statistical significance of the partitions. Few studies (17.2%) reported confidence intervals for the RI estimates. Overall, only 14.1% of studies...Continue Reading

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Citations

Jul 27, 2018·Critical Reviews in Clinical Laboratory Sciences·Yesim OzardaUNKNOWN IFCC Committee on Reference intervals and Decision Limits (C-RIDL)
Feb 6, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Rainer HaeckelThomas Streichert
Sep 24, 2020·Scientific Reports·Rafal N WlazelTomasz Kostka

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Methods Mentioned

BETA
ELISA

Software Mentioned

DistillerSR

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