Statistical Model of Optical Coherence Tomography Angiography Parameters That Correlate With Severity of Diabetic Retinopathy

Investigative Ophthalmology & Visual Science
Mohammed AshrafAmani A Fawzi

Abstract

To determine whether combining quantitative optical coherence tomography angiography (OCTA) parameters can achieve high sensitivity and specificity to distinguish eyes with nonproliferative diabetic retinopathy (NPDR) from those with proliferative diabetic retinopathy (PDR) as well as eyes with diabetes and no DR (NoDR) from those with clinical DR (any DR). This cross-sectional study included 28 eyes (17 patients) with NoDR, 54 eyes (34 patients) with NPDR, and 56 eyes (36 patients) with PDR. OCTA images were processed to quantify the foveal avascular zone (FAZ) area, acircularity, vessel density, skeletonized vessel density, fractal dimension, and intersections and average vessel diameter for the superficial (SCP) and the deep capillary plexus (DCP). Binary logistic regression models were used to identify the OCTA parameters that best distinguished DR severity groups. The area (AUC) under the receiver operating characteristic (ROC) curves, and sensitivity and specificity were calculated for each model. The regression model identified the SCP FAZ area, DCP vessel density, and acircularity as parameters that best distinguished between DR severity groups. ROC curves for NPDR versus PDR had an AUC of 0.845 (P < 0.001) and sensitiv...Continue Reading

Associated Clinical Trials

References

Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Nov 1, 2011·Investigative Ophthalmology & Visual Science·Johnny TamAustin Roorda
Jun 5, 2015·Biomaterials·Nathan A HotalingCarl G Simon
May 18, 2016·American Journal of Ophthalmology·Qian WangWen Bin Wei
Jul 15, 2016·Investigative Ophthalmology & Visual Science·Colin S TanSriniVas R Sadda
Jul 30, 2016·Investigative Ophthalmology & Visual Science·Devanshi BhanushaliAbhijit Sinha Roy
Sep 23, 2016·Investigative Ophthalmology & Visual Science·Sarwar ZahidJoshua A Young
Oct 28, 2017·Investigative Ophthalmology & Visual Science·Sean T GarrityDavid Sarraf
Jan 25, 2018·The British Journal of Ophthalmology·Harpal Singh SandhuAyman El-Baz
May 26, 2018·Investigative Ophthalmology & Visual Science·Alex C OnishiAmani A Fawzi

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Citations

Sep 2, 2019·Current Diabetes Reports·Changyow C Kwan, Amani A Fawzi
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Apr 15, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alexandra M CoffeyPaul A Constable
Oct 6, 2020·Therapeutic Advances in Ophthalmology·Hamid SafiKhalil Ghasemi Falavarjani
Sep 4, 2020·Vestnik oftalmologii·D V Petrachkov, M V Budzinskaya
Jun 21, 2019·Journal of Clinical Medicine·Minhaj AlamXincheng Yao
Jul 15, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Naiqiang XieWenyong Huang
May 3, 2019·Investigative Ophthalmology & Visual Science·Edmund ArthurStephen A Burns
Nov 24, 2019·Ophthalmology·Christina J FlaxelGui-Shuang Ying
Feb 23, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Martin Dominik LeclaireMaged Alnawaiseh
Apr 22, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Maged AlnawaisehNicole Eter
May 27, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·Shariq HashmiJoshua Young

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Software Mentioned

DiameterJ
ImageJ
AngioVue Analytics
SSADA
Fractalyse
OCTA
AngioVue

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