Statistical Modeling of Retinal Optical Coherence Tomography

IEEE Transactions on Medical Imaging
Zahra Amini, Hossein Rabbani

Abstract

In this paper, a new model for retinal Optical Coherence Tomography (OCT) images is proposed. This statistical model is based on introducing a nonlinear Gaussianization transform to convert the probability distribution function (pdf) of each OCT intra-retinal layer to a Gaussian distribution. The retina is a layered structure and in OCT each of these layers has a specific pdf which is corrupted by speckle noise, therefore a mixture model for statistical modeling of OCT images is proposed. A Normal-Laplace distribution, which is a convolution of a Laplace pdf and Gaussian noise, is proposed as the distribution of each component of this model. The reason for choosing Laplace pdf is the monotonically decaying behavior of OCT intensities in each layer for healthy cases. After fitting a mixture model to the data, each component is gaussianized and all of them are combined by Averaged Maximum A Posterior (AMAP) method. To demonstrate the ability of this method, a new contrast enhancement method based on this statistical model is proposed and tested on thirteen healthy 3D OCTs taken by the Topcon 3D OCT and five 3D OCTs from Age-related Macular Degeneration (AMD) patients, taken by Zeiss Cirrus HD-OCT. Comparing the results with two c...Continue Reading

References

Aug 22, 2001·IEEE Transactions on Medical Imaging·A AchimP Tsakalides
May 13, 2006·IEEE Transactions on Medical Imaging·Kim L BoyerCynthia Roberts
Mar 16, 2007·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Sos S AgaianKaren A Panetta
Aug 8, 2007·IEEE Transactions on Medical Imaging·Harry M Salinas, Delia Cabrera Fernández
Aug 21, 2008·IEEE Transactions on Bio-medical Engineering·Hossein RabbaniSaeed Gazor
Aug 22, 2009·IEEE Transactions on Bio-medical Engineering·Hossein RabbaniSaeed Gazor
Mar 23, 2010·IEEE Transactions on Medical Imaging·Norberto Mauricio GrzywaczCarlo Bruni
Feb 26, 2011·IEEE Transactions on Neural Networks·Valero LaparraJesús Malo
May 10, 2011·Investigative Ophthalmology & Visual Science·Michaël J A GirardJean Martial Mari
Apr 12, 2013·Physics in Medicine and Biology·Raheleh KafiehMilan Sonka
Sep 1, 2012·IEEE Computer Graphics and Applications·Cindy Grimm, G Elisabeta Marai

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Citations

May 5, 2017·PloS One·Danilo A JesusD Robert Iskander
May 21, 2017·Journal of Medical Systems·Mohammad S ImtiazKhan A Wahid
Mar 27, 2018·Journal of Biomedical Optics·Ashkan AbbasiHossein Rabbani
Jan 20, 2017·Biomedical Optics Express·Danilo A Jesus, D Robert Iskander

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