Statistical power analysis for hemodynamic cardiovascular safety pharmacology studies in beagle dogs

Journal of Pharmacological and Toxicological Methods
Alan Y ChiangR Dustan Sarazan

Abstract

We studied the statistical power of a replicated Latin square design where eight animals each receive a vehicle control and three dose levels of a drug on four separate dosing days. Cardiovascular parameters evaluated in the study were systolic arterial pressure, diastolic arterial pressure, left ventricular heart rate, and dP/dt(max). Observations were simulated based on historical data and drug response profiles from cardiovascular safety pharmacology studies conducted at Lilly Research Laboratories. Statistical analysis for treatment effects was performed using a linear mixed model. Monotonicity of dose response was examined using sequential linear trend tests based on ordinal spacing of dose levels. The replicated Latin square design for cardiovascular safety pharmacology studies is shown to have at least an 80% power of detecting changes from control of at least a 10% increment in systolic and diastolic pressure and a 15% increment in heart rate and dP/dt(max). The power is not sensitive to the shape of dose response profile over time. Several unique features of our statistical power evaluation include the comparison of different covariance structures and drug response profiles. The procedure can also be applied to future ...Continue Reading

References

Dec 1, 1969·Computers and Biomedical Research, an International Journal·M L Cohen
Dec 13, 2000·Statistics in Medicine·C CorcoranP Senchaudhuri
Jun 8, 2001·The British Journal of Mathematical and Statistical Psychology·H J KeselmanR K Kowalchuk
Jul 23, 2003·Trends in Pharmacological Sciences·Michael F W Festing

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Citations

Jun 24, 2010·Journal of Pharmacological and Toxicological Methods·A SivarajahN Edmunds
Jun 28, 2008·Journal of Pharmacological and Toxicological Methods·S AuthierE Troncy
Oct 23, 2010·Pharmaceutical Statistics·Mike AylottJim Saul
Mar 29, 2006·Journal of Pharmacological and Toxicological Methods·Alan Y ChiangDerek J Leishman
Apr 7, 2015·Journal of Pharmacological and Toxicological Methods·Brian D GuthR Dustan Sarazan
Apr 14, 2016·Journal of Pharmacological and Toxicological Methods·Siddhartha BhattJill Steidl-Nichols
Apr 28, 2016·Journal of Pharmacological and Toxicological Methods·Sabine RuppertMichael Hoffmann
Jan 10, 2017·Journal of Pharmacological and Toxicological Methods·Michael K PugsleyStanley T Parish

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