Statistical power in observer-performance studies: comparison of the receiver operating characteristic and free-response methods in tasks involving localization

Academic Radiology
D Chakraborty

Abstract

Statistical power, defined as the probability of detecting real differences between imaging modalities, determines the cost in terms of readers and cases of conducting receiver operating characteristic (ROC) studies. Neglect of location information in lesion-detection studies analyzed with the ROC method can compromise power. Use of the alternative free-response ROC (AFROC) method, which considers location information, has been discouraged, because it neglects intraimage correlations. The relative statistical powers of the two methods, however, have not been tested. The purpose of this study was to compare the statistical power of ROC and AFROC methods using simulations. A new model including intraimage correlations was developed to describe the decision variable sampling and to simulate data for ROC and AFROC analyses. Five readers and 200 cases (half of which contained one signal) were simulated for each trial. Two hundred trials, equally split between the null hypothesis and alternative hypothesis, were run. Ratings were analyzed with the Dorfman-Berbaum-Metz method, and separation of the null hypothesis and alternative hypothesis distributions was calculated. The AFROC method yielded higher power than the ROC method. Separa...Continue Reading

Citations

Jun 4, 2005·Radiation Protection Dosimetry·Dev P Chakraborty
Jul 11, 2006·Journal of Biomedical Optics·Brian W PogueKeith D Paulsen
Oct 5, 2013·Medical Physics·Ruey-Feng ChangWoo Kyung Moon
Sep 21, 2004·Medical Physics·Dev P Chakraborty, Kevin S Berbaum
Dec 17, 2005·AJR. American Journal of Roentgenology·Taku YasumotoHironobu Nakamura
Apr 6, 2006·The British Journal of Radiology·D ManningT Crawford
Jul 26, 2005·Radiology·C Leon PartainG Scott Gazelle
Nov 13, 2007·Journal of Biomedical Optics·Xiaomei SongTor D Tosteson
Feb 4, 2010·Journal of Digital Imaging·Rangaraj M RangayyanJ E Leo Desautels
Jan 1, 2008·Radiological Physics and Technology·Charles E Metz
Apr 22, 2004·Journal of Computer Assisted Tomography·Aravind ManiChristopher F Beaulieu
Jul 28, 2007·Medical Physics·Hong Jun YoonDev P Chakraborty
Feb 18, 2010·Radiation Protection Dosimetry·F ZancaH Bosmans
Mar 31, 2012·International Journal of Computer Assisted Radiology and Surgery·Shantanu BanikJ E Leo Desautels

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