Statistical primer: sample size and power calculations-why, when and how?

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Graeme L HickeyMatthias Siepe

Abstract

When designing a clinical study, a fundamental aspect is the sample size. In this article, we describe the rationale for sample size calculations, when it should be calculated and describe the components necessary to calculate it. For simple studies, standard formulae can be used; however, for more advanced studies, it is generally necessary to use specialized statistical software programs and consult a biostatistician. Sample size calculations for non-randomized studies are also discussed and two clinical examples are used for illustration.

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Citations

Aug 14, 2020·Scandinavian Journal of Medicine & Science in Sports·Haifeng ZhangJinlei Nie
Jan 17, 2019·Archives of public health = Archives belges de santé publique·Olaoluwa S AgbajeIjeoma R Nnaji
Aug 28, 2019·Journal of Clinical Medicine·Giulia LorenzoniFranco Pisanò
Oct 10, 2019·Revista latino-americana de enfermagem·Luis Manuel Fernández-Cacho, Rosa Ayesa-Arriola
May 31, 2019·Archives of public health = Archives belges de santé publique·Eyuche L OzoemenaEnejoh Anthony
Apr 23, 2020·Journal of Psychosomatic Obstetrics and Gynaecology·İlkay BozFerdane Duman
Jul 25, 2019·Journal of Neurophysiology·Franca DeriuAndrea Manca
Jan 20, 2021·BMJ : British Medical Journal·Luke WolfendenSze Lin Yoong
Dec 31, 2020·International Journal of Environmental Research and Public Health·Óscar Rodríguez-NogueiraArrate Pinto-Carral
Jan 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Timea Claudia GhiteaOtilia Micle
Oct 24, 2020·International Journal of Environmental Research and Public Health·Shuaijun GuoOrkan Okan
May 1, 2021·Archives of public health = Archives belges de santé publique·Olaoluwa Samson AgbajeCharles Chike Abba
Jun 7, 2021·Musculoskeletal Science & Practice·Arianne Verhagen, Ly-Mee Yu
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Sep 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Claire FalzaranoStanley Andrisse
Dec 30, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Konstantinos Eleftheriadis, Robert Davies
Jan 14, 2022·Interactive Cardiovascular and Thoracic Surgery·Mateo Marin-CuartasY Joseph Woo

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