PMID: 6162748Jan 1, 1980Paper

Statistical studies on thrombotic complications and the incidence of endocarditis neoplastic diseases

Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
P Stosiek, U Stosiek

Abstract

On the basis of data gained by autopsy the frequency of thrombotic and thromboembolic complications (TTK) was investigated by correlation analysis in unselected malignant tumour diseases and in malignant tumour diseases with tumour endocarditis (TE). The following things could be detected: 1. No increase of TTK in malignant tumour diseases compared with the total material, 2. A significant increase of TTK in tumours with TE, 3. A significant increase of TTK with an increasing histological tumour differentiation and an increasing inflammatory current reaction of the tumour, and 4. Parallel behaviour of tumours with TTK and those with TE concerning primary tumours. TTK was interpreted as the cause of an abnormally enhanced tendency of blood coagulation on the basis of an immunocomplex disease, because: 1. The coagulation system is being activated by circulating immunocomplexes, 2. Circulating immunocomplexes will increase with tumour parameters, differentiation, and current reaction, and 3. Frequency of TTK and TE will increase with the same parameters.

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