Status and perspective of lab-on-a-chip systems for common diseases: a systematic review from 2003 to 2013

Personalized Medicine
Alexander GebauerWolfgang Hoffmann

Abstract

Lab-on-a-chip systems (LOCs) are a useful aid for the individualization of therapeutic algorithms at the point-of-care. We performed a systematic literature review on LOCs for diseases with a global impact for healthcare. A total of 1007 articles matched the previously specified search criteria, thereof 65 studies could be included in this review. A total of 55 different LOCs were evaluated, most for diagnosis or monitoring of cancer (n = 24). For other diseases we found considerably less analyzed LOCs. The analytical performance of the LOCs was usually very good, 37 (67%) LOCs had a sensitivity higher than 90%. Although LOC systems performance has been positively evaluated in the great majority of studies, the testing was mostly limited to the research laboratory setting rather than real-world scenarios.

References

Sep 18, 1998·Emergency Medicine Clinics of North America·D M CharJ Ladenson
May 24, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jae Soon AhnEui Yul Choi
Jan 25, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiao-Mian ZhouBing-Cheng Lin
Feb 17, 2005·JAMA : the Journal of the American Medical Association·H Barton GrossmanYu Shen
Mar 25, 2005·Pediatric Diabetes·William V TamborlaneUNKNOWN Diabetes Research in Children Network (DirecNet) Study Group
Jul 15, 2005·PLoS Medicine·William R RodriguezJohn T McDevitt
Mar 7, 2006·Nature Reviews. Drug Discovery·Petra S Dittrich, Andreas Manz
Jul 27, 2006·AIDS·Laura G WesolowskiUNKNOWN Post-marketing Surveillance Team
Jul 28, 2006·Nature·Paul YagerBernhard H Weigl
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar
Apr 7, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Xuanhong ChengWilliam R Rodriguez
Aug 1, 2007·Arthritis and Rheumatism·Holger BangGerd-R Burmester
Feb 21, 2008·American Journal of Clinical Pathology·Suchitra PandeyDavid A Herold
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Nov 27, 2009·Analytical Chemistry·Zuankai WangSamuel K Sia
Feb 25, 2010·Chemical Society Reviews·Daniel MarkRoland Zengerle
Mar 25, 2010·Cancer Prevention Research·Shannon E WeigumJohn T McDevitt
Apr 14, 2010·Biomarkers in Medicine·Craig S MillerJohn T McDevitt
May 14, 2010·Analytical Chemistry·Arun AroraAndreas Manz
Jul 14, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sekesai Mtapuri-ZinyoweraTrevor Peter
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henry K LinRichard J Cote
Oct 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shannon L StottMehmet Toner
Jan 14, 2011·Nature·George Poste
Feb 25, 2011·Science Translational Medicine·Jered B HaunRalph Weissleder
Mar 29, 2011·Advances in Dental Research·N W JohnsonJ Phelan
Jun 28, 2011·Arthritis Research & Therapy·Piyanka E ChandraWilliam H Robinson
Jul 8, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Georg HansmannShashi K Murthy
Aug 2, 2011·Nature Medicine·Curtis D ChinSamuel K Sia
Aug 23, 2011·Biosensors & Bioelectronics·Hatice Ceylan KoydemirGülşen Hasçelik
Aug 30, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ming ShiFanggui Ye
Sep 13, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Papa Alassane DiawTandakha Ndiaye Dieye

❮ Previous
Next ❯

Citations

Dec 12, 2020·PloS One·Gabriel Santos RosalemMaria Gabriela Reis Carvalho

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
nuclear magnetic resonance
electrophoresis
enzyme-linked immunosorbent assay
fluorescence imaging
chips

Software Mentioned

SciFinder
OraQuick
BioMedSearch

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved