PMID: 3758290Oct 1, 1986Paper

Status epilepticus facilitated by pilocarpine in amygdala-kindled rats

Experimental Neurology
G G ButerbaughD O Keyser

Abstract

A novel model of status epilepticus based on the kindling model of epilepsy is described. The model involves the administration of a small dose of pilocarpine (20 mg/kg) to rats that have been previously kindled. Stimulation of these pretreated rats produces seizures which continue uninterrupted for approximately 4 h before spontaneous termination. The electroencephalographic discharge pattern showed characteristic changes in polarity and amplitude throughout the duration of status epilepticus. Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode. Animals that had been partially kindled to stage II seizures did not develop status epilepticus after stimulation when pretreated with pilocarpine, indicating that prior kindling is integral to the development of status epilepticus in this model. Administration of scopolamine was ineffective in terminating the condition when it had begun, suggesting that cholinergic stimulation is necessary for the initiation, but not the maintenance, of status epilepticus. This model holds promise for the study of status epilepticus because the condition develops in a ...Continue Reading

Citations

Jul 1, 1989·Brain Research. Brain Research Reviews·R S Fisher
Jan 1, 1993·Epilepsia·C G WasterlainR Sankar
Sep 24, 2011·Neurosurgery Clinics of North America·John D RolstonRobert E Gross
Mar 17, 2007·Acta Neurologica Scandinavica·J W Y ChenC G Wasterlain
Jun 1, 1987·Experimental Neurology·J P Vicedomini, J V Nadler
Feb 21, 2006·Lancet Neurology·James W Y Chen, Claude G Wasterlain
Jul 9, 2016·Annals of the New York Academy of Sciences·Jerome NiquetClaude G Wasterlain
Feb 1, 1997·Journal of Child Neurology·U Kramer, S Harel
Dec 20, 2018·Epilepsia Open·Kerry W ThompsonClaude G Wasterlain

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