Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study

Epilepsia
Jaak NairismägiHana Kubová

Abstract

Whether status epilepticus (SE) in early infancy, rather than the underlying illness, leads to temporal lobe neurodegeneration and volume reduction remains controversial. SE was induced with LiCl-pilocarpine in P12 rats. To assess acute neuronal damage, brains (five controls, five with SE) were investigated at 8 h after SE by using silver and Fluoro-Jade B staining. Some brains from the early phase were processed for electron microscopy. To assess chronic changes, brains from nine controls and 13 rats with SE at P12 were analyzed after 3 months by using histology and magnetic resonance imaging (MRI). MRI analysis of the temporal lobe of adult animals with SE at P12 indicated that 23% of the rats had hippocampal, 15% had amygdaloid, and 31% had perirhinal volume reduction. Histologic analysis of sections from the MR-imaged brains correlated with the MRI data. Analysis of neurodegeneration 8 h after SE by using both silver and Fluoro-Jade B staining revealed degenerating neurons located in the same temporal lobe regions as the volume reduction in chronic samples. Electron microscopic analysis revealed irreversible ultrastructural alterations. As with the chronic histologic and MRI findings, interanimal variability was seen in the...Continue Reading

References

Sep 1, 1990·Neurology·C H Chan
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1984·Brain : a Journal of Neurology·W F Brown, T E Feasby
Apr 1, 1984·Brain Research·J E Franck, P A Schwartzkroin
Jan 14, 1994·Brain Research. Developmental Brain Research·D Chang, T Z Baram
May 20, 1997·Brain Research. Developmental Brain Research·K Thompson, C Wasterlain
Oct 7, 1998·Epilepsy Research·A PitkänenT Salmenperä
Feb 12, 1999·Brain Research. Developmental Brain Research·N PineauA Nehlig
Jul 31, 2001·The Journal of Comparative Neurology·R D Burwell
Aug 17, 2002·Brain : a Journal of Neurology·Rod C ScottA Connelly
Jun 26, 2004·The European Journal of Neuroscience·Hana KubováAsla Pitkänen
Jul 15, 2004·Advances in Experimental Medicine and Biology·Roland A BenderTallie Z Baram
Sep 25, 2004·Annals of Neurology·Céline DubéTallie Z Baram

❮ Previous
Next ❯

Citations

Aug 11, 2010·Epilepsy Currents·F Edward DudekKevin J Staley
May 24, 2008·Anesthesia and Analgesia·Andreas W Loepke, Sulpicio G Soriano
Nov 22, 2013·PloS One·Svetlana KantorovichPaul R Carney
Mar 22, 2008·AJR. American Journal of Roentgenology·James M ProvenzaleDarrell V Lewis
Sep 8, 2012·Epilepsy Research and Treatment·Emilie Sheppard, Sarah Lippé
Mar 17, 2011·Neurobiology of Disease·Steve GibbsLionel Carmant
Nov 26, 2010·Epilepsy Research·Selene LomoioElda Scherini
Nov 3, 2009·Neurobiology of Disease·Maria-Leonor Lopez-MerazJerome Niquet
Aug 19, 2008·Neurobiology of Disease·Jacobus F A JansenGovert Hoogland
Jan 8, 2008·Epilepsy Research·Grygoriy TsenovPavel Mares
Dec 7, 2007·The European Journal of Neuroscience·Jessica R Sudbury, Massimo Avoli
Jan 30, 2013·Epilepsy Research·Liran DomachevskyCatherine Tempel-Brami
Oct 18, 2012·Neurobiology of Disease·Kate Elizabeth GillingJoachim Behr
Nov 16, 2013·Epilepsy & Behavior : E&B·Maria-Leonor López-MerazJorge Manzo
Mar 29, 2014·Epilepsy & Behavior : E&B·Genaro Alfonso Coria-AvilaMaria-Leonor López-Meraz
Dec 1, 2014·Neurobiology of Aging·Edoardo MicottiGianluigi Forloni
Jun 15, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·C Rincón-LópezM-L López-Meraz
Oct 30, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·D Hernández-MartínezM L López-Meraz
Oct 5, 2016·Experimental and Therapeutic Medicine·Liliana Carmona-AparicioNoemí Cárdenas-Rodríguez
Jun 12, 2020·Epilepsia Open·Pablo M Casillas-EspinosaTerence J O'Brien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.