Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration

Brain Research
Suman PatelMahendra Pratap Singh

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder contributed by the combination of age, genetic and environmental factors. Several studies have clearly shown increase in the incidences of PD in the rural environments and hypothesized the involvement of pesticides such as paraquat and maneb in neurodegeneration. These studies have prompted researchers to develop paraquat and maneb models to study the effect of co-treatment of maneb and paraquat on neuronal toxicity; however, the mechanism underlying maneb and paraquat co-treatment induced neuronal toxicity has not yet been clearly understood. The involvement of cytochrome P4502E1 and glutathione S-transferases A4-4 enzymes in the detoxification of several pesticides such as atrazine, fenamirol, organophosphorous insecticide parathion, methoxychlor, diethyl dithiocarbamate and paraquat has been known. The contribution of CYP2E1 and GSTA4-4 in neuronal toxicity has also been reported. The present study was therefore undertaken to investigate the mechanism of maneb- and paraquat-induced neurodegeneration by estimating the level of antioxidant defense enzymes in the striatum and measuring the differential expressions of CYP2E1 and GSTA4-4 genes. Animals were trea...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·J W Tetrud, J W Langston
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·M SaitoS D Aust
Apr 1, 1974·The Biochemical Journal·R C BrayL Calabrese
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Mar 1, 1995·Toxicology Letters·C Di IlioA Aceto
Jun 1, 1993·Toxicology Letters·A SiddiquiS P Srivastava
Feb 15, 1996·Biochemical and Biophysical Research Communications·E M SereeY Barra
Nov 27, 1995·Biochemical Pharmacology·J A O'Shaughnessy, L G Sultatos
Apr 1, 1997·Physiological Reviews·C S Lieber
Nov 14, 1997·Nutrition·H C Box, A E Maccubbin
Jun 1, 1997·Molecular and Chemical Neuropathology·J C GarciáM McPherson
Jan 27, 1999·Chemico-biological Interactions·N HaniokaK Ogawa
Jan 1, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D CentonzeG Bernardi
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Marí, A I Cederbaum
Sep 6, 2002·Biochemical Pharmacology·Srinivas BharathJulie K Andersen
Nov 14, 2002·Neurotoxicology·Donato A Di MonteAmy B Manning-Bog
Nov 14, 2002·Neurotoxicology·Mona ThiruchelvamDeborah A Cory-Slechta
Apr 25, 2003·British Journal of Pharmacology·Lisa A HowardRachel F Tyndale
Aug 16, 2003·Toxicology Letters·Luis F Oropeza-HernándezArnulfo Albores
Sep 25, 2004·Experimental Biology and Medicine·Qingfeng FanJianghong Deng
Apr 29, 2005·Journal of Neurochemistry·Alison L McCormackDonato A Di Monte

❮ Previous
Next ❯

Citations

May 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anand Kumar SinghMahendra Pratap Singh
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Emilia Grosicka-MaciągIwonna Rahden-Staroń
Jan 13, 2015·Molecular Neurobiology·Jing XiongTao Wang
Jun 24, 2010·Critical Reviews in Toxicology·Giuseppina GiusiMarcello Canonaco
Jan 20, 2010·Toxicology Mechanisms and Methods·Seema SinghMahendra Pratap Singh
Sep 23, 2014·Molecular Neurobiology·Ghanshyam UpadhyayRakesh K Srivastava
Apr 17, 2007·European Journal of Pharmacology·Ghanshyam UpadhyayMahendra Pratap Singh
Dec 31, 2016·Neurobiology of Aging·Franziska RichterMarie-Françoise Chesselet
Oct 23, 2010·Journal of Pineal Research·Naveen Kumar SinghalMahendra Pratap Singh
Aug 22, 2013·Molecular and Cellular Biochemistry·Naveen Kumar SinghalMahendra Pratap Singh
Feb 21, 2013·Human & Experimental Toxicology·R K SharmaB Sharma
May 17, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Colin C AndersonJames R Roede
Jan 19, 2010·Pharmacological Reports : PR·Bessy ThrashMuralikrishnan Dhanasekaran
Jun 28, 2018·Neurotoxicity Research·Manish Kumar TripathiMahendra Pratap Singh
Dec 7, 2020·Free Radical Biology & Medicine·Colin C AndersonJames R Roede
Sep 1, 2008·Environmental Toxicology and Pharmacology·Hamadi FetouiNajiba Zeghal
Sep 16, 2008·European Journal of Pharmacology·Ghanshyam UpadhyayMahendra Pratap Singh
Mar 27, 2009·Journal of Chromatography. a·Katia BuonaseraLuigi Mondello
Jun 6, 2009·Ecotoxicology and Environmental Safety·Mariana AstizCarlos Alberto Marra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.