Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity

Microbes and Infection
Tomoki YamashitaAkio Adachi

Abstract

We examined various HIV-1 Vif mutants for interaction with APOBEC3 proteins (A3G/A3F). All replication-defective proviral mutants were found to carry A3G/A3F in virions, and of these, a replication-defective mutant with Vif that binds to A3G in cells but not in virions was noted. Furthermore, a mutant Vif protein that suppresses A3F activity but does not exclude A3F from virions was identified. We also showed that incorporation of Vif into virions is dependent on its interaction with A3G/A3F. Taken together, we concluded that functional binding of Vif to A3G/A3F in cells and/or virions is critical for viral infectivity.

Citations

Oct 29, 2011·Cellular and Molecular Life Sciences : CMLS·Bin XueVladimir N Uversky
Jul 19, 2011·Journal of Molecular Biology·Elena Britan-RosichMoshe Kotler
Mar 20, 2010·The Journal of Medical Investigation : JMI·Tamiko NagaoAkio Adachi
Dec 19, 2012·Annual Review of Food Science and Technology·Julie E Samson, Sylvain Moineau
Sep 29, 2017·The Journal of Medical Investigation : JMI·Naoya DoiMasako Nomaguchi

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