Status of cochlear Na,K-ATPase in the aged SHR rat and its possible role in hearing loss

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
L Lippincott, K E Rarey

Abstract

The relationship between levels of Na,K-ATPase isoforms was studied in the lateral walls of the cochlea in aged spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Dense staining for the enzyme's alpha 1 subunit was found especially in the basal turns of the cochlea, while external sulcal cells were more intensely stained in the more apical turns in both SHR and WKY rats. In contrast, staining for beta 1 Na,K-ATPase was demonstrable in significant levels in the stria vascularis and suprastrial regions of the SHR rat, with involvement of the basilar suprastrial region pronounced in both strains of animals. Findings suggest a spatially defined, age-induced alteration in cochlear homeostasis with a possible consequent effect on sound perception.

Citations

Dec 14, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shusheng GongQing Chang
Apr 12, 2000·British Journal of Audiology·B KarlsmoseA Parving
Jul 3, 2021·International Journal of Molecular Sciences·Parveen BazardBo Ding

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