Status of high-risk oncogenic human papillomavirus subtypes harbored in the prepuce of prepubertal boys

Urology
Ayhan VeritMurat Savas

Abstract

To evaluate whether the high-risk human papillomavirus (HPV) subtypes that are strongly related to cervical cancer are harbored in the prepuce of the circumcised tissue of prepubertal boys in the period just before active sexual life. The present study enrolled 30 healthy boys (age range 4-11 years, mean age 8.1 ± 1.6) who underwent a standard circumcision procedure, with hypospadias repair in 3 patients. All prepuceal samples were studied using real-time polymerase chain reaction and grouped according to HPV subtype prevalence as groups 1 (types 16 and 18), 2 (types 31, 33, 45, 52, and 58), and 3 (types 35, 39, 51, 56, 59, 66, and 68). HPV DNA was reported in 25 (83.3%) of the 30 subjects. All samples showed a negative result for group 2. Although most of the positive findings were for group 3 (25 [83.3%] of 30), a positive result was reported for only 1 subject for group 1 (3.3%). The results of the present study have shown that the prepuce harbored the rarest HPV types, including types 35, 39, 51, 56, 59, 66, and 68 in preadolescence boys with a high rate (83%). These findings are in contrast to the common knowledge of HPV prevalence in adults that points to the dominance of HPV subtypes 16 and 18.

References

Oct 1, 1989·Archives of Sexual Behavior·H WielandtB Jeune
Jun 14, 2000·BMJ : British Medical Journal·R Szabo, R V Short
Apr 12, 2002·The New England Journal of Medicine·Xavier CastellsaguéUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S Syrjänen, M Puranen
Jun 6, 2003·Pediatric Dermatology·Jennifer PowellFenella Wojnarowska
Feb 10, 2004·The Journal of Infectious Diseases·Bethany A WeaverLaura A Koutsky
Nov 16, 2005·Reviews in Medical Virology·Christy M Hebner, Laimonis A Laimins
Sep 26, 2006·The Journal of Infection·Robert S Van Howe
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·Jean-Luc PrétetUNKNOWN EDITH study group
Oct 16, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Brian J Morris
Feb 19, 2008·Journal of Virological Methods·Tibor TakácsAttila Sebe
Feb 21, 2008·The Journal of Infectious Diseases·B Y HernandezM T Goodman
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Anna R GiulianoManuel Quiterio
Mar 10, 2009·American Journal of Obstetrics and Gynecology·Daniela DoerflerElmar A Joura
Mar 27, 2009·The New England Journal of Medicine·Aaron A R TobianRonald H Gray
Jan 19, 2010·Clinical Pediatrics·Marvin L WangElizabeth A Catlin
Oct 19, 2010·The Lancet Oncology·Silvia de SanjoseUNKNOWN Retrospective International Survey and HPV Time Trends Study Group
Jul 12, 2011·The Journal of Infectious Diseases·Marc BrissonMarie-Claude Boily
Aug 20, 2011·Sexual Health·Philippe BaumannJoan-Carles Suris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.