Status of insecticide resistance in high-risk malaria provinces in Afghanistan

Malaria Journal
Mushtaq AhmadMartijn Vink

Abstract

Insecticide resistance seriously threatens the efficacy of vector control interventions in malaria endemic countries. In Afghanistan, the status of insecticide resistance is largely unknown while distribution of long-lasting insecticidal nets has intensified in recent years. The main objective of this study was thus to measure the level of resistance to four classes of insecticides in provinces with medium to high risk of malaria transmission. Adult female mosquitoes were reared from larvae successively collected in the provinces of Nangarhar, Kunar, Badakhshan, Ghazni and Laghman from August to October 2014. WHO insecticide susceptibility tests were performed with DDT (4 %), malathion (5 %), bendiocarb (0.1 %), permethrin (0.75 %) and deltamethrin (0.05 %). In addition, the presence of kdr mutations was investigated in deltamethrin resistant and susceptible Anopheles stephensi mosquitoes collected in the eastern provinces of Nangarhar and Kunar. Analyses of mortality rates revealed emerging resistance against all four classes of insecticides in the provinces located east and south of the Hindu Kush mountain range. Resistance is observed in both An. stephensi and Anopheles culicifacies, the two dominant malaria vectors in these...Continue Reading

References

Mar 11, 2003·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mark RowlandRobert Wirtz
Apr 27, 2005·Lancet·Jan KolaczinskiMark Rowland
Dec 21, 2006·Emerging Infectious Diseases·Simon BrookerJan Kolaczinski
Feb 7, 2008·Emerging Infectious Diseases·Michael K FauldeAchim Hoerauf
Nov 5, 2011·Malaria Journal·Michael T WhiteAzra C Ghani
Apr 27, 2012·Journal of the American Mosquito Control Association·Saul Lozano-FuentesLars Eisen
Nov 28, 2012·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Zamonidin HabirovRalph E Harbach
Oct 8, 2013·Asian Pacific Journal of Tropical Biomedicine·Jalil NejatiSeyed Hasan Moosa-Kazemi

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Methods Mentioned

BETA
PCR
genotyping
PCRs

Software Mentioned

IR mapper
Qcal

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