Status of somatostatin receptor messenger RNAs and binding sites in rat brain during kindling epileptogenesis

Neuroscience
C PiwkoA Vezzani

Abstract

In situ hybridization histochemistry with somatostatin sst1-sst5 receptor messenger RNA-selective oligoprobes and quantitative receptor autoradiographic binding studies using [125I]Tyr3-octreotide, [Leu2,D-Trp22,125I-Tyr25]somatostatin-28 and [125I]CGP 23996 ([125I]c[Asn-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Tyr-Thr-Ser]) were performed to determine the level of expression of somatostatin receptor messenger RNA and receptor binding sites in the hippocampal formation, limbic system and cerebral cortex of adult rats electrically kindled in the dorsal hippocampus. In control rats (implanted with electrodes but not electrically stimulated), the somatostatin-1 receptor-selective [125I]Tyr3-octreotide and the non-subtype-selective [Leu3,D-Trp22,125I-Tyr25]somatostatin-28 preferentially labelled the strata oriens and radiatum of the CA1 subfield of the hippocampus, the molecular layer of the dentate gyrus, the subiculum and presubiculum of the hippocampal formation, the inner layer of the frontal cortex, and the lateral and basolateral nuclei of the amygdala. The non-subtype-selective radioligand [125I]CGP 23996 (in 5 mM Mg2+ buffer) preferentially labelled the strata oriens and radiatum of the CA1 subfield of the hippocampus, the subiculum and...Continue Reading

References

Oct 1, 1991·Brain Research. Molecular Brain Research·H ShinodaJ P Schwartz
Sep 1, 1990·Metabolism: Clinical and Experimental·P J Riekkinen, A Pitkänen
Aug 28, 1989·Brain Research·N C de LanerolleD D Spencer
Nov 1, 1985·Journal of the Neurological Sciences·M F BealJ B Martin
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
May 2, 1980·European Journal of Pharmacology·H R OlpeP Sieber
Sep 28, 1981·Brain Research·Q J Pittman, G R Siggins
Apr 1, 1983·Archives of General Psychiatry·D R RubinowS Reichlin
Nov 14, 1983·Brain Research·J EpelbaumY Agid
Dec 15, 1983·The New England Journal of Medicine·S Reichlin
Dec 22, 1983·The New England Journal of Medicine·S Reichlin
Nov 1, 1984·Journal of Neurochemistry·T HiguchiH G Friesen
Aug 1, 1995·Neuroscience·T Reisine, G I Bell
Mar 15, 1995·European Journal of Pharmacology·D HoyerJ C Reubi
Mar 1, 1995·Trends in Pharmacological Sciences·D HoyerJ E Taylor
Nov 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·D HoyerC Bruns
May 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·V S ThossD Hoyer
Feb 15, 1996·European Journal of Pharmacology·V S ThossD Hoyer

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Citations

Dec 3, 1999·The European Journal of Neuroscience·A Vezzani, D Hoyer
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helen E Scharfman
Jan 29, 2008·Molecular and Cellular Endocrinology·Melanie K Tallent, Cuie Qiu
Apr 14, 1999·Journal of Neurophysiology·M K Tallent, G R Siggins

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