Sep 26, 2013

Status of systemic oxidative stress during therapeutic hypothermia in patients with post-cardiac arrest syndrome

Oxidative Medicine and Cellular Longevity
Kenji DohiTohru Aruga

Abstract

Therapeutic hypothermia (TH) is thought to be due to the downregulation of free radical production, although the details of this process remain unclear. Here, we investigate changes in oxidative stress and endogenous biological antioxidant potential during TH in patients with post-cardiac arrest syndrome (PCAS). Nineteen PCAS patients were enrolled in the study. Brain temperature was decreased to the target temperature of 33°C, and it was maintained for 24 h. Patients were rewarmed slowly (0.1°C/h, <1°C/day). The generation of reactive oxygen metabolites (ROMs) was evaluated in plasma samples by d-ROM test. Plasma antioxidant capacity was measured by the biological antioxidant potential (BAP) test. Levels of d-ROMs and BAP levels during the hypothermic stage (33°C) were suppressed significantly compared with pre-TH induction levels (P < 0.05), while both d-ROM and BAP levels increased with rewarming (33-36°C) and were correlated with brain temperature. Clinical monitoring of oxidative stress and antioxidant potential is useful for evaluating the redox state of patients undergoing TH after PCAS. Additional therapy to support the antioxidant potential in the rewarming stage following TH may reduce some of the observed side effect...Continue Reading

  • References52
  • Citations13

References

  • References52
  • Citations13

Mentioned in this Paper

Antioxidants
Free Radicals
Oxidative Stress
Oxidative Stress Analysis
Down-Regulation
Hypothermia, Natural
Mild Hypothermia, Induced
Oxidation-Reduction
Metabolite
Reactive Oxygen Species

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Related Papers

Oxidative Medicine and Cellular Longevity
Fumiko NagatomoAkihiko Ishihara
Hypertension Research : Official Journal of the Japanese Society of Hypertension
Kazushi WatanabeAkihiko Wakatsuki
International Journal of Medical Sciences
Francesco InchingoloMarco Tatullo
© 2020 Meta ULC. All rights reserved