Status Report on COVID-19 Vaccines Development.

Current Infectious Disease Reports
Arun KumarPaul A Kristiansen


The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has affected lives of billions of individuals, globally. There is an urgent need to develop interventions including vaccines to control the ongoing pandemic. Development of tools for fast-tracked testing including small and large animal models for vaccine efficacy analysis, assays for immunogenicity assessment, critical reagents, international biological standards, and data sharing allowed accelerated development of vaccines. More than 300 vaccines are under development and 9 of them are approved for emergency use in various countries, with impressive efficacy ranging from 50 to 95%. Recently, several new SARS-CoV-2 variants have emerged and are circulating globally, and preliminary findings imply that some of them may escape immune responses against previous variants and diminish efficacy of current vaccines. Most of these variants acquired new mutations in their surface protein (Spike) which is the antigen in most of the approved/under development vaccines. In this review, we summarize novel and traditional approaches for COVID-19 vaccine development including inactivated, attenuated, nucleic acid, vector and protein based. Critical assessment o...Continue Reading


Apr 10, 2018·Frontiers in Immunology·Arun KumarSylvie Bertholet
Jul 25, 2018·Frontiers in Immunology·Leo Yi Yang LeeAeron C Hurt
Feb 26, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Giulietta MaruggiDong Yu
Mar 9, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Piotr S KowalskiDaniel G Anderson
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
May 22, 2020·Science·Jingyou YuDan H Barouch
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Neeltje van DoremalenVincent J Munster
Jul 9, 2020·BioRxiv : the Preprint Server for Biology·Flavia ChiuppesiFelix Wussow
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Jul 18, 2020·BioRxiv : the Preprint Server for Biology·James Brett CaseMichael S Diamond
Jul 30, 2020·The New England Journal of Medicine·Kizzmekia S CorbettBarney S Graham
Jul 31, 2020·Nature·Noe B MercadoDan H Barouch
Aug 14, 2020·Nature·Mark J MulliganKathrin U Jansen
Aug 14, 2020·JAMA : the Journal of the American Medical Association·Shengli XiaXiaoming Yang
Aug 17, 2020·Cell·Na-Na ZhangCheng-Feng Qin
Sep 3, 2020·The New England Journal of Medicine·Cheryl KeechGregory M Glenn
Sep 6, 2020·Nature Reviews. Drug Discovery·Tung Thanh LeStephen Mayhew
Sep 24, 2020·Nature·César Muñoz-FontelaDan H Barouch
Sep 30, 2020·The New England Journal of Medicine·Evan J AndersonUNKNOWN mRNA-1273 Study Group
Oct 15, 2020·BioRxiv : the Preprint Server for Biology·Rodney G KingScot Roberts
Oct 15, 2020·The New England Journal of Medicine·Edward E WalshWilliam C Gruber
Dec 11, 2020·The New England Journal of Medicine·Fernando P PolackUNKNOWN C4591001 Clinical Trial Group
Dec 18, 2020·Nature Communications·Yfat Yahalom-RonenTomer Israely
Dec 18, 2020·PLoS Genetics·Louis-Marie BobayHoward Ochman
Dec 31, 2020·The New England Journal of Medicine·Lindsey R BadenUNKNOWN COVE Study Group
Jan 28, 2021·BioRxiv : the Preprint Server for Biology·Kai WuDarin K Edwards
Feb 4, 2021·BioRxiv : the Preprint Server for Biology·Xiaoying ShenDavid C Montefiori

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May 19, 2021·Journal of the International AIDS Society·James G Kublin
Jun 22, 2021·Acta Clinica Belgica·Dorien G De MunckVeerle Matheeussen

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