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Staufen 1 amplifies pro-apoptotic activation of the unfolded protein response.

bioRxiv

Oct 28, 2019

Mandi GandelmanStefan Matthias Pulst

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Abstract

Staufen-1 (STAU1) is an RNA binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule associated protein tau (MAPT), huntingtin (HTT), TAR DNA-binding protein-43 gene (TARDBP) or ...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Autophagy
DNA-Binding Proteins
Fibroblasts
Laboratory mice
Microtubules
Nerve Degeneration
RNA-Binding Proteins
Tau Proteins
Apoptosis
9
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Staufen 1 amplifies pro-apoptotic activation of the unfolded protein response.

bioRxiv

Oct 28, 2019

Mandi GandelmanStefan Matthias Pulst

DOI: 10.1101/820225

Abstract

Staufen-1 (STAU1) is an RNA binding protein that becomes highly overabundant in numerous neurodegenerative disease models, including those carrying mutations in presenilin1 (PSEN1), microtubule associated protein tau (MAPT), huntingtin (HTT), TAR DNA-binding protein-43 gene (TARDBP) or ...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Autophagy
DNA-Binding Proteins
Fibroblasts
Laboratory mice
9

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