Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults.

The Cochrane Database of Systematic Reviews
Nandi SiegfriedGeorge W Rutherford

Abstract

A favourable regimen for people infected with HIV/AIDS is one that provides optimal efficacy, durability of antiretroviral activity, tolerability, and has low adverse effects and drug-drug interactions. The combination of the non-nucleoside reverse transcriptase inhibitor nevirapine (NVP), and two nucleoside reverse transcriptase inhibitors, stavudine (d4T) and lamivudine (3TC), is widely used as first-line therapy, especially in low-resource countries. Analysis of the efficacy, durability and tolerability of the regimen is thus important to clinicians, consumers and policy-makers living in both rich and poor countries. To examine the efficacy of the stavudine, lamivudine and nevirapine regimen for the treatment of HIV infection and AIDS in adults. We used the comprehensive search strategy developed specifically by the Cochrane HIV/AIDS Review Group to identify HIV/AIDS randomised controlled trials, and searched the following electronic databases: MEDLINE (searched July 2004); Embase (searched October 2004); and CENTRAL (July 2004). This search was supplemented with a search of AIDSearch (April 2005) to identify relevant conference abstracts, as well as searching reference lists of all eligible articles. The search was not limi...Continue Reading

References

Nov 7, 1998·BMJ : British Medical Journal·D G Altman
Jun 9, 2001·BMJ : British Medical Journal·I V Weller, I G Williams
Jan 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugenia NegredoBonaventura Clotet
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Robert M GrantJames O Kahn
Jul 4, 2002·JAMA : the Journal of the American Medical Association·Patrick G YeniPaul A Volberding
Sep 18, 2003·JAMA : the Journal of the American Medical Association·Frank van Leth, Joep M A Lange
Sep 27, 2003·HIV Medicine·A PozniakUNKNOWN BHIVA Writing Committee BHIVA Executive Committee
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Jul 24, 2004·The Journal of Infectious Diseases·UNKNOWN Collaboration of HIV Cohorts
Feb 18, 2005·The Journal of Infectious Diseases·Ian SanneFranck Rousseau
Aug 27, 2005·The New England Journal of Medicine·Diane V Havlir, Scott M Hammer

❮ Previous
Next ❯

Citations

Jun 10, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kevin PottieUNKNOWN coauthors of the Canadian Collaboration for Immigrant and Refugee Health
Jan 8, 2017·The Journal of Antimicrobial Chemotherapy·Daniel F CarrMunir Pirmohamed
Jun 30, 2011·European Child & Adolescent Psychiatry·Oluwole FamuyiwaOlufunlayo M Bankole-Oki
Jan 31, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel F CarrMunir Pirmohamed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.