Staying in touch with the endocytic network: The importance of contacts for cholesterol transport.

Traffic
Andrea MartelloEmily R Eden

Abstract

Cholesterol homeostasis is critical for cell function and human health. Cholesterol is heterogeneously distributed among cellular membranes, with the redistribution of endocytosed dietary cholesterol playing a pivotal role in the regulation of cholesterol homeostasis. While gaps remain in our understanding of intracellular dietary cholesterol transport, a highly complex network of pathways is starting to emerge, often involving inter-dependent vesicular and non-vesicular transport mechanisms. The last decade has seen a surge in interest in non-vesicular transport and inter-organellar communication at membrane contact sites. By providing platforms for protein interactions, signalling events, lipid exchange and calcium flux, membrane contact sites (MCS) are now appreciated as controlling the fate of large amounts of lipid and play central roles in the regulation and co-ordination of endocytic trafficking. Here, we review the role of MCS in multiple pathways for cholesterol export from the endocytic pathway and highlight the intriguing interplay between vesicular and non-vesicular transport mechanisms and relationship with neurodegenerative disease.

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Citations

Sep 16, 2020·Traffic·Yvonne Lange, Theodore L Steck
Nov 22, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Patricia García-SanzRosario Moratalla
Jul 28, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Beatriz S C SilvaMichael Schrader
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Louise H WongEmily R Eden
Jun 3, 2021·Nature Reviews. Molecular Cell Biology·Sara SigismundPier Paolo Di Fiore

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